STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
kynATryptophan 2,3-dioxygenase apoenzyme; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (276 aa)    
Predicted Functional Partners:
kynB
Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
 
 
 0.987
ADH62419.1
Aminotransferase class V; COGs: COG0520 Selenocysteine lyase; InterPro IPR015424:IPR000192:IPR015421; KEGG: sus:Acid_2875 kynureninase; PFAM: aminotransferase class V; SPTR: C1XY60 Selenocysteine lyase; PFAM: Aminotransferase class-V; TIGRFAM: kynureninase.
 
  
  0.947
ADH63709.1
COGs: COG0076 Glutamate decarboxylase and related PLP-dependent protein; InterProIPR015424:IPR015422:IPR002129:IPR010977:IPR 015421; KEGG: chl:Chy400_3078 aromatic-L-amino-acid decarboxylase; PFAM: Pyridoxal-dependent decarboxylase; SPTR: C1XT64 PLP-dependent enzyme, glutamate decarboxylase; PFAM: Pyridoxal-dependent decarboxylase conserved domain.
     
  0.900
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.812
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.800
ADH64526.1
Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein; COGs: COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL homologs; InterPro IPR008274:IPR000674; KEGG: tro:trd_1847 carbon monoxide dehydrogenase large chain; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; SPTR: C1XZ65 Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead dom [...]
     
 0.779
ADH64451.1
Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
    
   0.647
ADH64525.1
COGs: COG2421 acetamidase/formamidase; InterPro IPR004304; KEGG: ara:Arad_8681 acetamidase/formamidase protein; PFAM: Acetamidase/Formamidase; SPTR: C1XZ66 Predicted acetamidase/formamidase; PFAM: Acetamidase/Formamidase family.
       0.567
ADH64528.1
InterPro IPR002860; KEGG: gau:GAU_3646 hypothetical protein; PFAM: glycosyl hydrolase BNR repeat-containing protein; SPTR: C1XZ63 BNR/Asp-box repeat protein; PFAM: BNR/Asp-box repeat.
       0.517
ADH64529.1
InterPro IPR016155; KEGG: aca:ACP_1949 hypothetical protein; SPTR: C1XZ62 Putative uncharacterized protein.
       0.517
Your Current Organism:
Meiothermus silvanus
NCBI taxonomy Id: 526227
Other names: M. silvanus DSM 9946, Meiothermus silvanus ATCC 700542, Meiothermus silvanus DSM 9946, Meiothermus silvanus VI-R2, Meiothermus silvanus str. DSM 9946, Meiothermus silvanus strain DSM 9946
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