STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC106518200Alpha-synuclein; Belongs to the synuclein family. (127 aa)    
Predicted Functional Partners:
sncaip
Synphilin-1.
    
 0.943
park2
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
    
 
 0.847
LOC106523750
Apolipoprotein Eb-like.
    
 0.838
hspa4
Heat shock 70 kDa protein 4.
   
 
 0.763
LOC106523429
Heat shock 70 kDa protein 4-like isoform X1.
   
 
 0.763
park7
Protein deglycase DJ-1.
    
 
 0.759
apoe
Apolipoprotein E.
    
 0.759
LOC106533652
E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
    
 0.733
pink1
Serine/threonine-protein kinase PINK1, mitochondrial.
    
 
 0.707
slc6a2
Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
   
 
 0.701
Your Current Organism:
Austrofundulus limnaeus
NCBI taxonomy Id: 52670
Other names: A. limnaeus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.