STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sirt1NAD-dependent protein deacetylase sirtuin-1. (690 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.991
LOC106511592
Forkhead box protein O3-like.
    
 0.983
foxo3
Forkhead box protein O3.
    
 0.983
LOC106532649
Forkhead box protein O6-like.
    
 0.983
nampt
Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.
     
 0.960
nadsyn1
Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.
    
 0.954
LOC106530702
Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.
     
 0.947
nudt12
Peroxisomal NADH pyrophosphatase NUDT12.
    
 0.915
LOC106515510
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like.
     
 0.914
LOC106515511
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like.
     
 0.914
Your Current Organism:
Austrofundulus limnaeus
NCBI taxonomy Id: 52670
Other names: A. limnaeus
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