STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACWI_012305-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (191 aa)    
Predicted Functional Partners:
fgs
Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
 
  
 0.860
folD
Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.824
fchA
Methenyltetrahydrofolate cyclohydrolase.
    
 0.798
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
    
 0.789
gcvT_1
Aminomethyltransferase.
 
 
 0.665
fhs_1
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
   
 0.647
fhs_2
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
   
 0.647
fhs_3
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
   
 0.647
fhs_4
Formate--tetrahydrofolate ligase.
   
 0.647
purH
Bifunctional purine biosynthesis protein PurH.
    
 0.626
Your Current Organism:
Acetobacterium wieringae
NCBI taxonomy Id: 52694
Other names: A. wieringae, ATCC 43740, JCM 2380, LMG 7579, LMG:7579, strain C
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.