Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
acsE_15-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase. (265 aa)    
Predicted Functional Partners:
metH_2
Methionine synthase.
    0.867
yitJ
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.866
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.831
ACWI_34500
Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.
 
  
 0.812
acsC
Corrinoid/iron-sulfur protein large subunit.
 
 
 
 0.741
acsD
Corrinoid/iron-sulfur protein small subunit.
 
 
 
 0.731
ACWI_04090
Methylcobalamin:coenzyme M methyltransferase; Belongs to the uroporphyrinogen decarboxylase family.
 
     0.722
fhs_3
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
    
 0.720
fhs_1
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
    
 0.706
fhs_2
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
    
 0.670
Your Current Organism:
Acetobacterium wieringae
NCBI taxonomy Id: 52694
Other names: A. wieringae, ATCC 43740, JCM 2380, LMG 7579, LMG:7579, strain C
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