tmk protein (Acetobacterium wieringae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

tmk

Thymidylate kinase. (493 aa)

Predicted Functional Partners:

ppk

0.826

ppx

0.720

gppA_2

0.669

ACWI_21840

0.607

hemZ

0.551

hemN

0.551

ACWI_06520

0.550

vnfA_2

0.544

gppA_1

0.529

hicd

0.448

Your Current Organism:

Acetobacterium wieringae

NCBI taxonomy Id: 52694
Other names: A. wieringae, ATCC 43740, JCM 2380, LMG 7579, LMG:7579, strain C

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACWI_06520	tmk	ACWI_06520	ACWI_08230	CHAD domain protein.	Thymidylate kinase.	0.550
ACWI_21840	tmk	ACWI_21840	ACWI_08230	V4R domain protein.	Thymidylate kinase.	0.607
gppA_1	gppA_2	ACWI_01360	ACWI_18040	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	0.959
gppA_1	ppk	ACWI_01360	ACWI_18050	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	0.844
gppA_1	ppx	ACWI_01360	ACWI_18060	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Exopolyphosphatase.	0.924
gppA_1	tmk	ACWI_01360	ACWI_08230	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Thymidylate kinase.	0.529
gppA_2	gppA_1	ACWI_18040	ACWI_01360	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	0.959
gppA_2	ppk	ACWI_18040	ACWI_18050	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	0.971
gppA_2	ppx	ACWI_18040	ACWI_18060	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Exopolyphosphatase.	0.983
gppA_2	tmk	ACWI_18040	ACWI_08230	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	Thymidylate kinase.	0.669
hemN	tmk	ACWI_24960	ACWI_08230	Oxygen-independent coproporphyrinogen-III oxidase-like protein YqeR; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.	Thymidylate kinase.	0.551
hemN	vnfA_2	ACWI_24960	ACWI_29220	Oxygen-independent coproporphyrinogen-III oxidase-like protein YqeR; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.	Nitrogen fixation protein VnfA.	0.402
hemZ	tmk	ACWI_18950	ACWI_08230	Oxygen-independent coproporphyrinogen-III oxidase-like protein HemZ.	Thymidylate kinase.	0.551
hemZ	vnfA_2	ACWI_18950	ACWI_29220	Oxygen-independent coproporphyrinogen-III oxidase-like protein HemZ.	Nitrogen fixation protein VnfA.	0.402
hicd	tmk	ACWI_08220	ACWI_08230	Homoisocitrate dehydrogenase.	Thymidylate kinase.	0.448
ppk	gppA_1	ACWI_18050	ACWI_01360	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	0.844
ppk	gppA_2	ACWI_18050	ACWI_18040	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	0.971
ppk	ppx	ACWI_18050	ACWI_18060	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Exopolyphosphatase.	0.976
ppk	tmk	ACWI_18050	ACWI_08230	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Thymidylate kinase.	0.826
ppx	gppA_1	ACWI_18060	ACWI_01360	Exopolyphosphatase.	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.	0.924