| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACWI_08990 | fhs_1 | ACWI_08990 | ACWI_04190 | Tetrahydromethanopterin S-methyltransferase subunit H. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.900 |
| ACWI_08990 | fhs_2 | ACWI_08990 | ACWI_10800 | Tetrahydromethanopterin S-methyltransferase subunit H. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.900 |
| ACWI_08990 | fhs_3 | ACWI_08990 | ACWI_30940 | Tetrahydromethanopterin S-methyltransferase subunit H. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.900 |
| ACWI_08990 | glyA | ACWI_08990 | ACWI_35470 | Tetrahydromethanopterin S-methyltransferase subunit H. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
| ACWI_08990 | metF | ACWI_08990 | ACWI_20610 | Tetrahydromethanopterin S-methyltransferase subunit H. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.904 |
| ACWI_08990 | metH_3 | ACWI_08990 | ACWI_06250 | Tetrahydromethanopterin S-methyltransferase subunit H. | Methionine synthase. | 0.900 |
| ACWI_08990 | metH_5 | ACWI_08990 | ACWI_06400 | Tetrahydromethanopterin S-methyltransferase subunit H. | Methionine synthase. | 0.917 |
| ACWI_08990 | purH | ACWI_08990 | ACWI_28150 | Tetrahydromethanopterin S-methyltransferase subunit H. | Bifunctional purine biosynthesis protein PurH. | 0.900 |
| ACWI_08990 | purN | ACWI_08990 | ACWI_28160 | Tetrahydromethanopterin S-methyltransferase subunit H. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
| ACWI_08990 | yitJ | ACWI_08990 | ACWI_34490 | Tetrahydromethanopterin S-methyltransferase subunit H. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.904 |
| fhs_1 | ACWI_08990 | ACWI_04190 | ACWI_08990 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Tetrahydromethanopterin S-methyltransferase subunit H. | 0.900 |
| fhs_1 | fhs_2 | ACWI_04190 | ACWI_10800 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.904 |
| fhs_1 | fhs_3 | ACWI_04190 | ACWI_30940 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.900 |
| fhs_1 | glyA | ACWI_04190 | ACWI_35470 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |
| fhs_1 | metF | ACWI_04190 | ACWI_20610 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.559 |
| fhs_1 | metH_3 | ACWI_04190 | ACWI_06250 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase. | 0.928 |
| fhs_1 | metH_5 | ACWI_04190 | ACWI_06400 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase. | 0.900 |
| fhs_1 | purH | ACWI_04190 | ACWI_28150 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein PurH. | 0.970 |
| fhs_1 | purN | ACWI_04190 | ACWI_28160 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
| fhs_1 | yitJ | ACWI_04190 | ACWI_34490 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.465 |