| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adeC | apt | ACWI_06260 | ACWI_18910 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.955 |
| adeC | guaA_1 | ACWI_06260 | ACWI_01040 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.565 |
| adeC | guaB | ACWI_06260 | ACWI_01050 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.412 |
| adeC | hpt | ACWI_06260 | ACWI_01290 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Hypoxanthine-guanine phosphoribosyltransferase. | 0.761 |
| adeC | mtnP | ACWI_06260 | ACWI_02100 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. | 0.744 |
| adeC | xpt | ACWI_06260 | ACWI_25840 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.753 |
| apt | adeC | ACWI_18910 | ACWI_06260 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | 0.955 |
| apt | gmk | ACWI_18910 | ACWI_19070 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.891 |
| apt | guaA_1 | ACWI_18910 | ACWI_01040 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.980 |
| apt | guaB | ACWI_18910 | ACWI_01050 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.902 |
| apt | hpt | ACWI_18910 | ACWI_01290 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase. | 0.841 |
| apt | mtnP | ACWI_18910 | ACWI_02100 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. | 0.981 |
| apt | purB | ACWI_18910 | ACWI_20640 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.929 |
| apt | purH | ACWI_18910 | ACWI_28150 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional purine biosynthesis protein PurH. | 0.933 |
| apt | recJ | ACWI_18910 | ACWI_18900 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | single-stranded-DNA-specific exonuclease RecJ. | 0.815 |
| apt | xpt | ACWI_18910 | ACWI_25840 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.868 |
| gmk | apt | ACWI_19070 | ACWI_18910 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.891 |
| gmk | guaA_1 | ACWI_19070 | ACWI_01040 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.965 |
| gmk | guaB | ACWI_19070 | ACWI_01050 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.834 |
| gmk | hpt | ACWI_19070 | ACWI_01290 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine-guanine phosphoribosyltransferase. | 0.840 |