Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
iscS_3Cysteine desulfurase IscS. (387 aa)    
Predicted Functional Partners:
iscU_2
Iron-sulfur cluster assembly scaffold protein IscU.
 
 0.992
thiI
Putative tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.970
moeB_1
Molybdopterin-synthase adenylyltransferase.
 
 
 0.968
iscU_1
Iron-sulfur cluster assembly scaffold protein IscU.
 
 0.967
tusA
Sulfurtransferase TusA; Belongs to the sulfur carrier protein TusA family.
 
 
 
 0.935
ACWI_31780
Dinitrogenase iron-molybdenum cofactor.
  
 0.890
ACWI_02120
Hypothetical protein.
  
 0.887
sfrB_1
NADPH-Fe(3+) oxidoreductase subunit beta.
  
 0.848
sfrB_2
NADPH-Fe(3+) oxidoreductase subunit beta.
  
 0.848
cdr_4
Coenzyme A disulfide reductase; Belongs to the sulfur carrier protein TusA family.
   
 
 0.813
Your Current Organism:
Acetobacterium wieringae
NCBI taxonomy Id: 52694
Other names: A. wieringae, ATCC 43740, JCM 2380, LMG 7579, LMG:7579, strain C
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