thyA1 protein (Acetobacterium wieringae) - STRING interaction network

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thyA1

Thymidylate synthase 1. (248 aa)

Predicted Functional Partners:

dut

0.964

folD

0.956

glyA

0.952

tadA_1

0.937

thyX

0.929

metF

0.915

lpd_4

0.915

yitJ

0.915

ACWI_34500

0.914

rnfC_3

0.914

Your Current Organism:

Acetobacterium wieringae

NCBI taxonomy Id: 52694
Other names: A. wieringae, ATCC 43740, JCM 2380, LMG 7579, LMG:7579, strain C

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACWI_34500	folD	ACWI_34500	ACWI_34520	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.986
ACWI_34500	glyA	ACWI_34500	ACWI_35470	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.908
ACWI_34500	lpd_4	ACWI_34500	ACWI_24190	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	Dihydrolipoyl dehydrogenase.	0.692
ACWI_34500	metF	ACWI_34500	ACWI_20610	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.927
ACWI_34500	rnfC_3	ACWI_34500	ACWI_34510	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	Electron transport complex subunit RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.	0.980
ACWI_34500	thyA1	ACWI_34500	ACWI_28560	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	Thymidylate synthase 1.	0.914
ACWI_34500	thyX	ACWI_34500	ACWI_32390	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.900
ACWI_34500	yitJ	ACWI_34500	ACWI_34490	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.995
dut	tadA_1	ACWI_29290	ACWI_04830	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	tRNA-specific adenosine deaminase.	0.949
dut	thyA1	ACWI_29290	ACWI_28560	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Thymidylate synthase 1.	0.964
dut	thyX	ACWI_29290	ACWI_32390	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.930
folD	ACWI_34500	ACWI_34520	ACWI_34500	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	0.986
folD	glyA	ACWI_34520	ACWI_35470	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.982
folD	lpd_4	ACWI_34520	ACWI_24190	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Dihydrolipoyl dehydrogenase.	0.926
folD	metF	ACWI_34520	ACWI_20610	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.958
folD	rnfC_3	ACWI_34520	ACWI_34510	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Electron transport complex subunit RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.	0.973
folD	thyA1	ACWI_34520	ACWI_28560	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Thymidylate synthase 1.	0.956
folD	thyX	ACWI_34520	ACWI_32390	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.916
folD	yitJ	ACWI_34520	ACWI_34490	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.984
glyA	ACWI_34500	ACWI_35470	ACWI_34500	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.	0.908