Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
acsE_75-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase. (261 aa)    
Predicted Functional Partners:
acsC
Corrinoid/iron-sulfur protein large subunit.
 
 
 0.991
acsD
Corrinoid/iron-sulfur protein small subunit.
 
 
 
 0.958
yitJ
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.910
ACWI_32100
Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha.
 
   
 0.857
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.855
cooS1_2
Carbon monoxide dehydrogenase 1.
 
   
 0.852
minD_3
Septum site-determining protein MinD.
 
   
 0.851
ACWI_34500
Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.
 
  
 0.843
minD_2
Septum site-determining protein MinD.
 
   
 0.825
ACWI_29210
Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha.
 
   
 0.804
Your Current Organism:
Acetobacterium wieringae
NCBI taxonomy Id: 52694
Other names: A. wieringae, ATCC 43740, JCM 2380, LMG 7579, LMG:7579, strain C
Server load: low (12%) [HD]