node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fchA | fhs_1 | ACWI_34530 | ACWI_04190 | Methenyltetrahydrofolate cyclohydrolase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.758 |
fchA | fhs_2 | ACWI_34530 | ACWI_10800 | Methenyltetrahydrofolate cyclohydrolase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.701 |
fchA | fhs_3 | ACWI_34530 | ACWI_30940 | Methenyltetrahydrofolate cyclohydrolase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.701 |
fchA | fhs_4 | ACWI_34530 | ACWI_34540 | Methenyltetrahydrofolate cyclohydrolase. | Formate--tetrahydrofolate ligase. | 0.855 |
fchA | folD | ACWI_34530 | ACWI_34520 | Methenyltetrahydrofolate cyclohydrolase. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.973 |
fchA | gcvT_1 | ACWI_34530 | ACWI_02620 | Methenyltetrahydrofolate cyclohydrolase. | Aminomethyltransferase. | 0.887 |
fchA | glyA | ACWI_34530 | ACWI_35470 | Methenyltetrahydrofolate cyclohydrolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.553 |
fchA | purD | ACWI_34530 | ACWI_28140 | Methenyltetrahydrofolate cyclohydrolase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.571 |
fchA | yitJ | ACWI_34530 | ACWI_34490 | Methenyltetrahydrofolate cyclohydrolase. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.872 |
fhs_1 | fchA | ACWI_04190 | ACWI_34530 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase. | 0.758 |
fhs_1 | folD | ACWI_04190 | ACWI_34520 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.990 |
fhs_1 | gcvT_1 | ACWI_04190 | ACWI_02620 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase. | 0.883 |
fhs_1 | glyA | ACWI_04190 | ACWI_35470 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.831 |
fhs_1 | purD | ACWI_04190 | ACWI_28140 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.751 |
fhs_1 | yitJ | ACWI_04190 | ACWI_34490 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.708 |
fhs_2 | fchA | ACWI_10800 | ACWI_34530 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase. | 0.701 |
fhs_2 | folD | ACWI_10800 | ACWI_34520 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.987 |
fhs_2 | gcvT_1 | ACWI_10800 | ACWI_02620 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase. | 0.883 |
fhs_2 | glyA | ACWI_10800 | ACWI_35470 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.831 |
fhs_2 | purD | ACWI_10800 | ACWI_28140 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.751 |