| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACWI_23980 | cpdB | ACWI_23980 | ACWI_12300 | 5'-nucleotidase. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | 0.900 |
| ACWI_23980 | maf | ACWI_23980 | ACWI_04820 | 5'-nucleotidase. | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.900 |
| ACWI_23980 | nagD | ACWI_23980 | ACWI_12960 | 5'-nucleotidase. | Ribonucleotide monophosphatase NagD. | 0.900 |
| ACWI_23980 | pyrF | ACWI_23980 | ACWI_28390 | 5'-nucleotidase. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.900 |
| ACWI_23980 | pyrH | ACWI_23980 | ACWI_29410 | 5'-nucleotidase. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
| ACWI_23980 | upp | ACWI_23980 | ACWI_35580 | 5'-nucleotidase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.900 |
| cpdB | ACWI_23980 | ACWI_12300 | ACWI_23980 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase. | 0.900 |
| cpdB | maf | ACWI_12300 | ACWI_04820 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.900 |
| cpdB | nagD | ACWI_12300 | ACWI_12960 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Ribonucleotide monophosphatase NagD. | 0.900 |
| cpdB | pyrF | ACWI_12300 | ACWI_28390 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.905 |
| cpdB | pyrH | ACWI_12300 | ACWI_29410 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
| cpdB | upp | ACWI_12300 | ACWI_35580 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.905 |
| glyA | rpiB_1 | ACWI_35470 | ACWI_23540 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Ribose-5-phosphate isomerase B. | 0.944 |
| glyA | rpiB_2 | ACWI_35470 | ACWI_34110 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Ribose-5-phosphate isomerase B. | 0.732 |
| glyA | upp | ACWI_35470 | ACWI_35580 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.792 |
| maf | ACWI_23980 | ACWI_04820 | ACWI_23980 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 5'-nucleotidase. | 0.900 |
| maf | cpdB | ACWI_04820 | ACWI_12300 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | 0.900 |
| maf | nagD | ACWI_04820 | ACWI_12960 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Ribonucleotide monophosphatase NagD. | 0.900 |
| maf | pyrF | ACWI_04820 | ACWI_28390 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.900 |
| maf | pyrH | ACWI_04820 | ACWI_29410 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
