STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEL51507.1Phosphoribosyl-ATP pyrophosphatase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (88 aa)    
Predicted Functional Partners:
hisA
Similar to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase PRK00748; similar to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase of Firmicutes UniRef RepID=HIS4_CLOB1.
 
 0.999
hisE
Similar to phosphoribosyl-ATP pyrophosphatase PRK00400; similar to Phosphoribosyl-ATP pyrophosphatase of Bacillus cereus group UniRef RepID=HIS2_BACAN.
  
 0.999
hisF
Hypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.991
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.987
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.987
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.986
hisB
Similar to imidazoleglycerol-phosphate dehydratase PRK00951; similar to Imidazoleglycerol-phosphate dehydratase of Bacteria UniRef RepID=HIS7_LEUMM.
 
  
 0.986
hisZ
ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 
  
 0.955
EEL51509.1
Similar to histidinol-phosphatase PRK06740; similar to Histidinol-phosphatase of Bacillales UniRef RepID=Q3EX66_BACTI; Belongs to the PHP hydrolase family. HisK subfamily.
  
  
 0.920
hisC-2
Similar to histidinol-phosphate aminotransferase PRK01533; similar to Histidinol-phosphate aminotransferase 1 of Bacillales UniRef RepID=HIS81_BACAN; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.886
Your Current Organism:
Bacillus cereus Rock344
NCBI taxonomy Id: 526986
Other names: B. cereus Rock3-44, Bacillus cereus Rock3-44
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.