STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
disADNA integrity scanning protein disA; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. (357 aa)    
Predicted Functional Partners:
radA
DNA repair protein radA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.966
EEL52548.1
Similar to Integral membrane protein (PIN domain superfamily) COG4956; similar to Uncharacterized protein yacL of Firmicutes UniRef RepID=YACL_BACSU.
  
  
 0.704
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
    0.667
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
  
    0.651
EEL52543.1
Similar to Modulator of heat shock repressor CtsR, McsA COG3880; similar to Nucleotide excision repair protein, with UvrB/UvrC motif of Bacillaceae UniRef RepID=A0R8F1_BACAH.
  
    0.650
EEL52545.1
Negative regulator of genetic competence; Similar to ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones COG0542; similar to Negative regulator of genetic competence clpC/mecB of Bacteria UniRef RepID=CLPC_BACSU; Belongs to the ClpA/ClpB family.
  
    0.641
EEL52542.1
Transcriptional repressor, CtsR; Similar to Transcriptional repressor of class III stress genes COG4463; similar to Transcriptional repressor, CtsR of Geobacillus UniRef RepID=B4BT33_9BACI; Belongs to the CtsR family.
  
  
 0.489
EEL52377.1
Similar to DNA-dependent helicase II PRK11773; similar to ATP-dependent DNA helicase pcrA of Bacilli UniRef RepID=PCRA_BACSU.
   
    0.422
EEL51677.1
ATP-dependent DNA helicase, UvrD/REP; Similar to Superfamily I DNA and RNA helicases COG0210; similar to ATP-dependent DNA helicase, UvrD/REP family of Bacillus cereus group UniRef RepID=B0AXC8_BACAN.
   
    0.422
Your Current Organism:
Bacillus cereus Rock344
NCBI taxonomy Id: 526986
Other names: B. cereus Rock3-44, Bacillus cereus Rock3-44
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