A0A4S8JBE4 protein (Musa balbisiana) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

A0A4S8JBE4

Uncharacterized protein. (536 aa)

Predicted Functional Partners:

A0A4S8KF25

0.637

A0A4S8IJI6

0.588

A0A4S8J1Y2

0.464

A0A4V4H4Y6

0.464

A0A4V4H954

0.464

A0A4S8KBG3

0.438

A0A4S8JZD9

0.409

A0A4S8J155

0.404

Your Current Organism:

Musa balbisiana

NCBI taxonomy Id: 52838
Other names: Balbis banana, M. balbisiana, Musa BB Group, Musa balbisiana Colla, starchy banana

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A4S8IJI6	A0A4S8J1Y2	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.981
A0A4S8IJI6	A0A4S8JBE4	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Uncharacterized protein.	0.588
A0A4S8IJI6	A0A4S8KF25	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.996
A0A4S8IJI6	A0A4V4H4Y6	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Uncharacterized protein.	0.981
A0A4S8IJI6	A0A4V4H954	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.981
A0A4S8J155	A0A4S8JBE4	Uncharacterized protein.	Uncharacterized protein.	0.404
A0A4S8J155	A0A4S8JZD9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.985
A0A4S8J1Y2	A0A4S8IJI6	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.981
A0A4S8J1Y2	A0A4S8JBE4	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Uncharacterized protein.	0.464
A0A4S8J1Y2	A0A4S8KF25	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.980
A0A4S8JBE4	A0A4S8IJI6	Uncharacterized protein.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.588
A0A4S8JBE4	A0A4S8J155	Uncharacterized protein.	Uncharacterized protein.	0.404
A0A4S8JBE4	A0A4S8J1Y2	Uncharacterized protein.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.464
A0A4S8JBE4	A0A4S8JZD9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.409
A0A4S8JBE4	A0A4S8KBG3	Uncharacterized protein.	PA domain-containing protein.	0.438
A0A4S8JBE4	A0A4S8KF25	Uncharacterized protein.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.637
A0A4S8JBE4	A0A4V4H4Y6	Uncharacterized protein.	Uncharacterized protein.	0.464
A0A4S8JBE4	A0A4V4H954	Uncharacterized protein.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.464
A0A4S8JZD9	A0A4S8J155	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.985
A0A4S8JZD9	A0A4S8JBE4	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.409

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.901

expected number of edges:

28

PPI enrichment p-value:

0.000165

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031398

Positive regulation of protein ubiquitination

5 of 12

2.94

5.24

1.84e-10

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

4 of 4

3.32

4.94

1.04e-09

GO:1901987

Regulation of cell cycle phase transition

6 of 88

2.15

4.16

1.04e-09

GO:0031145

Anaphase-promoting complex-dependent catabolic process

4 of 16

2.72

4.07

2.25e-08

GO:0010564

Regulation of cell cycle process

7 of 160

1.96

3.98

2.61e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

4 of 4

3.32

4.69

3.06e-09

GO:0010997

Anaphase-promoting complex binding

4 of 4

3.32

4.69

3.06e-09

GO:0044877

Protein-containing complex binding

5 of 201

1.72

2.16

7.50e-06

GO:0004672

Protein kinase activity

4 of 431

1.29

0.89

0.0064

GO:0140096

Catalytic activity, acting on a protein

5 of 1397

0.87

0.5

0.0336

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005680

Anaphase-promoting complex

4 of 16

2.72

3.72

1.11e-07

GO:0000776

Kinetochore

4 of 45

2.27

2.93

1.61e-06

GO:0005815

Microtubule organizing center

3 of 78

1.91

1.64

0.00046

GO:0072686

Mitotic spindle

2 of 21

2.3

1.4

0.0024

GO:0005816

Spindle pole body

2 of 41

2.01

1.14

0.0066

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2484

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

8 of 28

2.78

8.78

6.03e-18

CL:2486

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

7 of 22

2.82

8.01

3.58e-16

CL:2488

Anaphase-promoting complex, and Mitotic checkpoint complex

4 of 17

2.69

3.86

5.69e-08

CL:2512

Mitotic checkpoint complex, and Mad3/Bub1 homology region 1

3 of 5

3.1

3.23

1.34e-06

CL:14564

Cohesin complex, and Meiotic spindle

2 of 10

2.62

1.34

0.0036

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

7 of 135

2.04

4.66

6.95e-12

map04111

Cell cycle - yeast

9 of 267

1.85

4.62

3.56e-14

map04120

Ubiquitin mediated proteolysis

4 of 198

1.63

1.72

8.87e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

5 of 18

2.76

5.07

2.68e-10

MAP-453276

Regulation of mitotic cell cycle

5 of 27

2.59

4.71

8.02e-10

MAP-174143

APC/C-mediated degradation of cell cycle proteins

5 of 27

2.59

4.71

8.02e-10

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

3 of 6

3.02

3.27

1.06e-06

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

3 of 6

3.02

3.27

1.06e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033597

Mitotic checkpoint complex

4 of 4

3.32

4.79

2.00e-09

GOCC:0015630

Microtubule cytoskeleton

4 of 130

1.81

1.76

0.00018

GOCC:0005819

Spindle

2 of 41

2.01

0.71

0.0470

GOCC:0110165

Cellular anatomical entity

11 of 10647

0.33

0.25

0.0470

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 149

1.75

1.76

0.00014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033010

The WD repeat Cdc20/Fizzy family

4 of 4

3.32

4.52

6.29e-09

IPR015661

Mitotic spindle checkpoint protein Bub1/Mad3

2 of 2

3.32

1.59

0.0014

IPR013212

Mad3/Bub1 homology region 1

2 of 2

3.32

1.59

0.0014

IPR001680

WD40 repeat

4 of 164

1.71

1.35

0.0014

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

4 of 202

1.62

1.3

0.0014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00777

Mad3/BUB1 hoMad3/BUB1 homology region 1

2 of 2

3.32

1.9

0.00038

SM00320

WD40 repeats

4 of 174

1.68

1.55

0.00038

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