A0A4S8K773 protein (Musa balbisiana) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A4S8K773

Uncharacterized protein. (735 aa)

Predicted Functional Partners:

A0A4S8KF25

0.637

A0A4S8IJI6

0.588

A0A4S8IFQ0

0.477

A0A4S8IJY2

0.477

A0A4S8J1Y2

0.464

A0A4V4H4Y6

0.464

A0A4V4H954

0.464

A0A4S8IXL1

0.410

A0A4S8JZD9

0.409

A0A4S8J155

0.404

Your Current Organism:

Musa balbisiana

NCBI taxonomy Id: 52838
Other names: Balbis banana, M. balbisiana, Musa BB Group, Musa balbisiana Colla, starchy banana

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A4S8IFQ0	A0A4S8IJY2	PORR domain-containing protein.	Uncharacterized protein.	0.561
A0A4S8IFQ0	A0A4S8IXL1	PORR domain-containing protein.	Uncharacterized protein.	0.443
A0A4S8IFQ0	A0A4S8K773	PORR domain-containing protein.	Uncharacterized protein.	0.477
A0A4S8IJI6	A0A4S8J1Y2	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.981
A0A4S8IJI6	A0A4S8K773	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Uncharacterized protein.	0.588
A0A4S8IJI6	A0A4S8KF25	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.996
A0A4S8IJI6	A0A4V4H4Y6	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Uncharacterized protein.	0.981
A0A4S8IJI6	A0A4V4H954	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.981
A0A4S8IJY2	A0A4S8IFQ0	Uncharacterized protein.	PORR domain-containing protein.	0.561
A0A4S8IJY2	A0A4S8IXL1	Uncharacterized protein.	Uncharacterized protein.	0.443
A0A4S8IJY2	A0A4S8K773	Uncharacterized protein.	Uncharacterized protein.	0.477
A0A4S8IXL1	A0A4S8IFQ0	Uncharacterized protein.	PORR domain-containing protein.	0.443
A0A4S8IXL1	A0A4S8IJY2	Uncharacterized protein.	Uncharacterized protein.	0.443
A0A4S8IXL1	A0A4S8J155	Uncharacterized protein.	Uncharacterized protein.	0.454
A0A4S8IXL1	A0A4S8K773	Uncharacterized protein.	Uncharacterized protein.	0.410
A0A4S8J155	A0A4S8IXL1	Uncharacterized protein.	Uncharacterized protein.	0.454
A0A4S8J155	A0A4S8JZD9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.985
A0A4S8J155	A0A4S8K773	Uncharacterized protein.	Uncharacterized protein.	0.404
A0A4S8J1Y2	A0A4S8IJI6	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	0.981
A0A4S8J1Y2	A0A4S8K773	Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.	Uncharacterized protein.	0.464

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.899

expected number of edges:

16

PPI enrichment p-value:

0.00167

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000077

DNA damage checkpoint signaling

3 of 19

2.26

1.44

0.0020

GO:0035556

Intracellular signal transduction

5 of 207

1.44

1.14

0.0020

GO:0007017

Microtubule-based process

3 of 78

1.64

0.93

0.0125

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005200

Structural constituent of cytoskeleton

3 of 6

2.76

2.27

6.71e-05

GO:0005509

Calcium ion binding

3 of 68

1.7

0.87

0.0188

GO:0005525

GTP binding

3 of 129

1.42

0.71

0.0313

GO:0004674

Protein serine/threonine kinase activity

3 of 152

1.35

0.66

0.0378

GO:0035639

Purine ribonucleoside triphosphate binding

6 of 896

0.88

0.55

0.0188

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005856

Cytoskeleton

6 of 258

1.42

1.62

2.93e-05

GO:0005874

Microtubule

3 of 57

1.78

1.27

0.0025

GO:0015630

Microtubule cytoskeleton

4 of 140

1.51

1.17

0.0022

GO:0099080

Supramolecular complex

4 of 158

1.46

1.13

0.0023

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 1135

0.85

0.66

0.0025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2438

Tubulin, and Kinetochore adaptor activity

5 of 5

3.06

5.46

8.66e-11

CL:3119

Mixed, incl. EF-hand domain, and Calmodulin binding

3 of 21

2.21

1.78

0.00039

CL:9794

Sensing of DNA Double Strand Breaks, and G2/M DNA damage checkpoint

2 of 13

2.24

1.02

0.0129

CL:3120

Mixed, incl. Myosin II complex, and Actin filament bundle

2 of 14

2.21

1.01

0.0135

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04145

Phagosome

4 of 66

1.84

2.02

4.41e-05

map04070

Phosphatidylinositol signaling system

3 of 48

1.85

1.52

0.00079

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9668328

Sealing of the nuclear envelope (NE) by ESCRT-III

4 of 16

2.46

3.06

1.44e-06

MAP-5617833

Cilium Assembly

4 of 29

2.2

2.71

4.03e-06

MAP-75035

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

3 of 7

2.69

2.66

1.20e-05

MAP-2995410

Nuclear Envelope (NE) Reassembly

4 of 42

2.04

2.39

1.20e-05

MAP-1852241

Organelle biogenesis and maintenance

4 of 46

2.0

2.36

1.20e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005823

Central plaque of spindle pole body

3 of 3

3.06

2.75

1.01e-05

GOCC:0005856

Cytoskeleton

6 of 221

1.49

1.82

1.01e-05

GOCC:0015630

Microtubule cytoskeleton

4 of 131

1.54

1.27

0.0013

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 1061

0.88

0.71

0.0015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0493

Microtubule

3 of 16

2.33

2.06

0.00012

KW-0206

Cytoskeleton

3 of 19

2.26

2.04

0.00012

KW-0342

GTP-binding

3 of 56

1.79

1.39

0.0013

KW-0106

Calcium

2 of 40

1.76

0.79

0.0285

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037103

Tubulin/FtsZ-like, C-terminal domain

3 of 4

2.93

2.36

5.02e-05

IPR023123

Tubulin, C-terminal

3 of 4

2.93

2.36

5.02e-05

IPR018316

Tubulin/FtsZ, 2-layer sandwich domain

3 of 4

2.93

2.36

5.02e-05

IPR017975

Tubulin, conserved site

3 of 4

2.93

2.36

5.02e-05

IPR008280

Tubulin/FtsZ, C-terminal

3 of 4

2.93

2.36

5.02e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00865

Tubulin/FtsZ family, C-terminal domain

3 of 4

2.93

2.86

5.82e-06

SM00864

Tubulin/FtsZ family, GTPase domain

3 of 4

2.93

2.86

5.82e-06

SM00240

Forkhead associated domain

2 of 10

2.36

1.24

0.0051

SM00054

EF-hand, calcium binding motif

2 of 16

2.15

1.1

0.0088

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