A0A4S8K7Q8 protein (Musa balbisiana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A4S8K7Q8

Uncharacterized protein. (494 aa)

Predicted Functional Partners:

A0A4S8JI21

0.955

A0A4S8IZJ7

0.952

A0A4S8K0R4

0.952

A0A4S8JSL9

0.945

A0A4S8JSF0

0.937

A0A4S8JJY7

0.927

A0A4S8INI5

0.923

A0A4S8JXA5

0.923

A0A4S8IA02

0.921

A0A4S8K1D4

0.921

Your Current Organism:

Musa balbisiana

NCBI taxonomy Id: 52838
Other names: Balbis banana, M. balbisiana, Musa BB Group, Musa balbisiana Colla, starchy banana

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A4S8IA02	A0A4S8INI5	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Uncharacterized protein.	0.927
A0A4S8IA02	A0A4S8IZJ7	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family.	0.968
A0A4S8IA02	A0A4S8JJY7	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Uncharacterized protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.	0.814
A0A4S8IA02	A0A4S8JSF0	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Aldedh domain-containing protein.	0.944
A0A4S8IA02	A0A4S8JSL9	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.822
A0A4S8IA02	A0A4S8JXA5	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Uncharacterized protein.	0.937
A0A4S8IA02	A0A4S8K0R4	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family.	0.968
A0A4S8IA02	A0A4S8K1D4	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.912
A0A4S8IA02	A0A4S8K7Q8	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Uncharacterized protein.	0.921
A0A4S8INI5	A0A4S8IA02	Uncharacterized protein.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.927
A0A4S8INI5	A0A4S8JSF0	Uncharacterized protein.	Aldedh domain-containing protein.	0.919
A0A4S8INI5	A0A4S8JSL9	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.810
A0A4S8INI5	A0A4S8JXA5	Uncharacterized protein.	Uncharacterized protein.	0.902
A0A4S8INI5	A0A4S8K1D4	Uncharacterized protein.	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.928
A0A4S8INI5	A0A4S8K7Q8	Uncharacterized protein.	Uncharacterized protein.	0.923
A0A4S8IZJ7	A0A4S8IA02	Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.968
A0A4S8IZJ7	A0A4S8JI21	Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family.	Uncharacterized protein.	0.600
A0A4S8IZJ7	A0A4S8JJY7	Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family.	Uncharacterized protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.	0.888
A0A4S8IZJ7	A0A4S8JSF0	Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family.	Aldedh domain-containing protein.	0.974
A0A4S8IZJ7	A0A4S8JSL9	Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.960

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Network Stats

number of nodes:

9

number of edges:

19

average node degree:

4.22

avg. local clustering coefficient:

0.858

expected number of edges:

9

PPI enrichment p-value:

0.00314

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006914

Autophagy

5 of 90

1.7

1.88

8.13e-05

GO:0061709

Reticulophagy

2 of 4

2.66

1.02

0.0187

GO:0016236

Macroautophagy

3 of 46

1.77

0.93

0.0187

GO:0000422

Autophagy of mitochondrion

2 of 8

2.35

0.89

0.0289

GO:0034727

Piecemeal microautophagy of the nucleus

2 of 14

2.11

0.75

0.0495

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000407

Phagophore assembly site

4 of 25

2.16

2.64

1.04e-05

GO:0034045

Phagophore assembly site membrane

3 of 13

2.32

2.15

0.00014

GO:0005773

Vacuole

6 of 186

1.46

1.83

1.04e-05

GO:0005776

Autophagosome

2 of 2

2.96

1.7

0.0013

GO:0005774

Vacuolar membrane

4 of 133

1.43

1.22

0.0015

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11059

Mixed, incl. Autophagy - other, and Organic cation transport

6 of 37

2.17

4.3

1.61e-09

CL:11064

Autophagy - other, and Lipase (class 3)

4 of 23

2.2

2.87

3.83e-06

CL:11096

Atg1/ULK1 kinase complex, and Phagophore assembly site

3 of 7

2.59

2.64

2.39e-05

CL:11119

Mixed, incl. Peptidase M18, and Lysosomal oligosaccharide catabolism

2 of 7

2.41

1.24

0.0071

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

4 of 23

2.2

3.03

1.72e-06

map04138

Autophagy - yeast

4 of 98

1.57

1.61

0.00020

map04139

Mitophagy - yeast

3 of 48

1.75

1.51

0.00091

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9612973

Autophagy

5 of 60

1.88

2.59

3.13e-06

MAP-1632852

Macroautophagy

5 of 60

1.88

2.59

3.13e-06

MAP-9663891

Selective autophagy

3 of 30

1.96

1.51

0.0015

MAP-8934903

Receptor Mediated Mitophagy

2 of 9

2.3

1.07

0.0137

MAP-5205647

Mitophagy

2 of 19

1.98

0.78

0.0415

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034045

Phagophore assembly site membrane

3 of 15

2.26

1.76

0.00073

GOCC:0005776

Autophagosome

2 of 2

2.96

1.58

0.0021

GOCC:0034270

Cvt complex

2 of 3

2.78

1.52

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0072

Autophagy

2 of 9

2.3

1.08

0.0132

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