SMAX5B_007733 protein (Scophthalmus maximus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

SMAX5B_007733

Transmembrane protein 60. (133 aa)

Predicted Functional Partners:

SMAX5B_006025

0.540

SMAX5B_005989

0.540

SMAX5B_013817

0.540

SMAX5B_009239

0.540

SMAX5B_004707

0.540

SMAX5B_022308

0.540

SMAX5B_014680

0.519

SMAX5B_010062

0.497

SMAX5B_022459

0.497

SMAX5B_013168

0.497

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SMAX5B_004707	SMAX5B_005989	ENSSMAP00000027528	ENSSMAP00000015339	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	0.845
SMAX5B_004707	SMAX5B_006025	ENSSMAP00000027528	ENSSMAP00000008579	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Putative phosphatidylinositol 3-kinase regulatory subunit beta-like.	0.804
SMAX5B_004707	SMAX5B_007733	ENSSMAP00000027528	ENSSMAP00000000503	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Transmembrane protein 60.	0.540
SMAX5B_004707	SMAX5B_009239	ENSSMAP00000027528	ENSSMAP00000025782	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Uncharacterized protein.	0.802
SMAX5B_004707	SMAX5B_010062	ENSSMAP00000027528	ENSSMAP00000003354	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Tyrosine-protein kinase receptor.	0.912
SMAX5B_004707	SMAX5B_013168	ENSSMAP00000027528	ENSSMAP00000017138	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Tyrosine-protein kinase receptor.	0.912
SMAX5B_004707	SMAX5B_013817	ENSSMAP00000027528	ENSSMAP00000019050	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Putative phosphatidylinositol 3-kinase regulatory subunit alpha.	0.802
SMAX5B_004707	SMAX5B_022308	ENSSMAP00000027528	ENSSMAP00000034377	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	0.844
SMAX5B_004707	SMAX5B_022459	ENSSMAP00000027528	ENSSMAP00000007561	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	Tyrosine-protein kinase receptor.	0.764
SMAX5B_005989	SMAX5B_004707	ENSSMAP00000015339	ENSSMAP00000027528	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	0.845
SMAX5B_005989	SMAX5B_006025	ENSSMAP00000015339	ENSSMAP00000008579	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Putative phosphatidylinositol 3-kinase regulatory subunit beta-like.	0.804
SMAX5B_005989	SMAX5B_007733	ENSSMAP00000015339	ENSSMAP00000000503	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Transmembrane protein 60.	0.540
SMAX5B_005989	SMAX5B_009239	ENSSMAP00000015339	ENSSMAP00000025782	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Uncharacterized protein.	0.802
SMAX5B_005989	SMAX5B_010062	ENSSMAP00000015339	ENSSMAP00000003354	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Tyrosine-protein kinase receptor.	0.912
SMAX5B_005989	SMAX5B_013168	ENSSMAP00000015339	ENSSMAP00000017138	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Tyrosine-protein kinase receptor.	0.912
SMAX5B_005989	SMAX5B_013817	ENSSMAP00000015339	ENSSMAP00000019050	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Putative phosphatidylinositol 3-kinase regulatory subunit alpha.	0.803
SMAX5B_005989	SMAX5B_022308	ENSSMAP00000015339	ENSSMAP00000034377	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	0.846
SMAX5B_005989	SMAX5B_022459	ENSSMAP00000015339	ENSSMAP00000007561	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	Tyrosine-protein kinase receptor.	0.872
SMAX5B_006025	SMAX5B_004707	ENSSMAP00000008579	ENSSMAP00000027528	Putative phosphatidylinositol 3-kinase regulatory subunit beta-like.	Putative phosphatidylinositol 3-kinase regulatory subunit alpha-like.	0.804
SMAX5B_006025	SMAX5B_005989	ENSSMAP00000008579	ENSSMAP00000015339	Putative phosphatidylinositol 3-kinase regulatory subunit beta-like.	Putative phosphatidylinositol 3-kinase regulatory subunit gamma-like.	0.804

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.805

expected number of edges:

12

PPI enrichment p-value:

1.44e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000271

Polysaccharide biosynthetic process

6 of 58

1.32

1.38

8.66e-05

GO:0009059

Macromolecule biosynthetic process

9 of 230

0.9

0.85

7.05e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016740

Transferase activity

9 of 397

0.66

0.49

0.0041

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

9 of 617

0.47

0.31

0.0342

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1869

Bacterial sugar transferase, and NUBPL iron-transfer P-loop NTPase

4 of 11

1.86

2.07

3.46e-05

CL:1871

Bacterial sugar transferase, and NUBPL iron-transfer P-loop NTPase

3 of 6

2.0

1.75

0.00033

CL:1863

Mixed, incl. O-Antigen nucleotide sugar biosynthesis, and Bacterial sugar transferase

6 of 58

1.32

1.5

2.23e-05

CL:1864

Mixed, incl. O-Antigen nucleotide sugar biosynthesis, and Bacterial sugar transferase

5 of 45

1.35

1.41

9.97e-05

CL:1859

Carbohydrate metabolic process, and Transferase

9 of 156

1.06

1.23

1.29e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0808

Transferase

10 of 332

0.78

0.75

1.10e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02397

Bacterial sugar transferase

4 of 6

2.13

2.47

1.09e-05

PF00535

Glycosyl transferase family 2

5 of 14

1.86

2.43

3.75e-06

PF13727

CoA-binding domain

2 of 2

2.3

1.0

0.0144

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