CLSPN protein (Scophthalmus maximus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CLSPN

Putative claspin isoform 2. (1331 aa)

Predicted Functional Partners:

ENSSMAP00000016430

0.989

ENSSMAP00000028620

0.989

SMAX5B_010328

0.984

SMAX5B_008050

0.978

SMAX5B_011489

0.975

SMAX5B_009864

0.968

RPA1

0.968

SMAX5B_014144

0.965

SMAX5B_006131

0.954

SMAX5B_006405

0.948

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	ENSSMAP00000016430	ENSSMAP00000001461	ENSSMAP00000016430	Putative claspin isoform 2.	Checkpoint kinase 1.	0.989
CLSPN	ENSSMAP00000028620	ENSSMAP00000001461	ENSSMAP00000028620	Putative claspin isoform 2.	Replication protein A3.	0.989
CLSPN	RPA1	ENSSMAP00000001461	ENSSMAP00000032241	Putative claspin isoform 2.	Replication protein A1.	0.968
CLSPN	SMAX5B_006131	ENSSMAP00000001461	ENSSMAP00000005776	Putative claspin isoform 2.	DNA helicase; Belongs to the MCM family.	0.954
CLSPN	SMAX5B_006405	ENSSMAP00000001461	ENSSMAP00000031739	Putative claspin isoform 2.	DNA helicase; Belongs to the MCM family.	0.948
CLSPN	SMAX5B_008050	ENSSMAP00000001461	ENSSMAP00000002151	Putative claspin isoform 2.	DNA helicase; Belongs to the MCM family.	0.978
CLSPN	SMAX5B_009864	ENSSMAP00000001461	ENSSMAP00000009636	Putative claspin isoform 2.	Putative replication protein A 70 kDa DNA-binding subunit.	0.968
CLSPN	SMAX5B_010328	ENSSMAP00000001461	ENSSMAP00000009856	Putative claspin isoform 2.	CDC45-related protein isoform 2.	0.984
CLSPN	SMAX5B_011489	ENSSMAP00000001461	ENSSMAP00000012701	Putative claspin isoform 2.	Putative DNA-directed primase/polymerase protein.	0.975
CLSPN	SMAX5B_014144	ENSSMAP00000001461	ENSSMAP00000006725	Putative claspin isoform 2.	Uncharacterized protein.	0.965
ENSSMAP00000016430	CLSPN	ENSSMAP00000016430	ENSSMAP00000001461	Checkpoint kinase 1.	Putative claspin isoform 2.	0.989
ENSSMAP00000016430	ENSSMAP00000028620	ENSSMAP00000016430	ENSSMAP00000028620	Checkpoint kinase 1.	Replication protein A3.	0.726
ENSSMAP00000016430	RPA1	ENSSMAP00000016430	ENSSMAP00000032241	Checkpoint kinase 1.	Replication protein A1.	0.785
ENSSMAP00000016430	SMAX5B_006131	ENSSMAP00000016430	ENSSMAP00000005776	Checkpoint kinase 1.	DNA helicase; Belongs to the MCM family.	0.886
ENSSMAP00000016430	SMAX5B_006405	ENSSMAP00000016430	ENSSMAP00000031739	Checkpoint kinase 1.	DNA helicase; Belongs to the MCM family.	0.994
ENSSMAP00000016430	SMAX5B_008050	ENSSMAP00000016430	ENSSMAP00000002151	Checkpoint kinase 1.	DNA helicase; Belongs to the MCM family.	0.897
ENSSMAP00000016430	SMAX5B_009864	ENSSMAP00000016430	ENSSMAP00000009636	Checkpoint kinase 1.	Putative replication protein A 70 kDa DNA-binding subunit.	0.785
ENSSMAP00000016430	SMAX5B_010328	ENSSMAP00000016430	ENSSMAP00000009856	Checkpoint kinase 1.	CDC45-related protein isoform 2.	0.989
ENSSMAP00000016430	SMAX5B_014144	ENSSMAP00000016430	ENSSMAP00000006725	Checkpoint kinase 1.	Uncharacterized protein.	0.906
ENSSMAP00000028620	CLSPN	ENSSMAP00000028620	ENSSMAP00000001461	Replication protein A3.	Putative claspin isoform 2.	0.989

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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