SMAX5B_016592 protein (Scophthalmus maximus)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

SMAX5B_016592

Putative E3 ubiquitin-protein ligase TRIM36. (725 aa)

Predicted Functional Partners:

SMAX5B_000286

0.587

SMAX5B_010010

0.577

SMAX5B_010224

0.569

ENSSMAP00000008002

0.566

SMAX5B_004116

0.537

ENSSMAP00000001280

0.525

SMAX5B_008461

0.511

ENSSMAP00000003962

0.507

SMAX5B_008251

0.494

SMAX5B_006530

0.493

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000001280	ENSSMAP00000003962	ENSSMAP00000001280	ENSSMAP00000003962	Leucine-rich repeats and guanylate kinase domain containing.	Zinc finger, AN1-type domain 4.	0.498
ENSSMAP00000001280	ENSSMAP00000008002	ENSSMAP00000001280	ENSSMAP00000008002	Leucine-rich repeats and guanylate kinase domain containing.	Ribosomal protein S27a.	0.475
ENSSMAP00000001280	SMAX5B_000286	ENSSMAP00000001280	ENSSMAP00000032950	Leucine-rich repeats and guanylate kinase domain containing.	Putative tonsoku-like protein-like isoform 2.	0.689
ENSSMAP00000001280	SMAX5B_008251	ENSSMAP00000001280	ENSSMAP00000011108	Leucine-rich repeats and guanylate kinase domain containing.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.478
ENSSMAP00000001280	SMAX5B_010010	ENSSMAP00000001280	ENSSMAP00000021816	Leucine-rich repeats and guanylate kinase domain containing.	Putative p53-induced protein with a death domain-like.	0.798
ENSSMAP00000001280	SMAX5B_010224	ENSSMAP00000001280	ENSSMAP00000033482	Leucine-rich repeats and guanylate kinase domain containing.	GMP synthase.	0.765
ENSSMAP00000001280	SMAX5B_016592	ENSSMAP00000001280	ENSSMAP00000001938	Leucine-rich repeats and guanylate kinase domain containing.	Putative E3 ubiquitin-protein ligase TRIM36.	0.525
ENSSMAP00000003962	ENSSMAP00000001280	ENSSMAP00000003962	ENSSMAP00000001280	Zinc finger, AN1-type domain 4.	Leucine-rich repeats and guanylate kinase domain containing.	0.498
ENSSMAP00000003962	ENSSMAP00000008002	ENSSMAP00000003962	ENSSMAP00000008002	Zinc finger, AN1-type domain 4.	Ribosomal protein S27a.	0.999
ENSSMAP00000003962	SMAX5B_000286	ENSSMAP00000003962	ENSSMAP00000032950	Zinc finger, AN1-type domain 4.	Putative tonsoku-like protein-like isoform 2.	0.771
ENSSMAP00000003962	SMAX5B_008251	ENSSMAP00000003962	ENSSMAP00000011108	Zinc finger, AN1-type domain 4.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.964
ENSSMAP00000003962	SMAX5B_010010	ENSSMAP00000003962	ENSSMAP00000021816	Zinc finger, AN1-type domain 4.	Putative p53-induced protein with a death domain-like.	0.755
ENSSMAP00000003962	SMAX5B_016592	ENSSMAP00000003962	ENSSMAP00000001938	Zinc finger, AN1-type domain 4.	Putative E3 ubiquitin-protein ligase TRIM36.	0.507
ENSSMAP00000008002	ENSSMAP00000001280	ENSSMAP00000008002	ENSSMAP00000001280	Ribosomal protein S27a.	Leucine-rich repeats and guanylate kinase domain containing.	0.475
ENSSMAP00000008002	ENSSMAP00000003962	ENSSMAP00000008002	ENSSMAP00000003962	Ribosomal protein S27a.	Zinc finger, AN1-type domain 4.	0.999
ENSSMAP00000008002	SMAX5B_000286	ENSSMAP00000008002	ENSSMAP00000032950	Ribosomal protein S27a.	Putative tonsoku-like protein-like isoform 2.	0.855
ENSSMAP00000008002	SMAX5B_008251	ENSSMAP00000008002	ENSSMAP00000011108	Ribosomal protein S27a.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
ENSSMAP00000008002	SMAX5B_010010	ENSSMAP00000008002	ENSSMAP00000021816	Ribosomal protein S27a.	Putative p53-induced protein with a death domain-like.	0.752
ENSSMAP00000008002	SMAX5B_016592	ENSSMAP00000008002	ENSSMAP00000001938	Ribosomal protein S27a.	Putative E3 ubiquitin-protein ligase TRIM36.	0.566
SMAX5B_000286	ENSSMAP00000001280	ENSSMAP00000032950	ENSSMAP00000001280	Putative tonsoku-like protein-like isoform 2.	Leucine-rich repeats and guanylate kinase domain containing.	0.689

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.919

expected number of edges:

11

PPI enrichment p-value:

4.03e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030983

Mismatched DNA binding

2 of 2

2.5

1.17

0.0073

GO:0140664

ATP-dependent DNA damage sensor activity

2 of 3

2.33

1.11

0.0090

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 176

1.1

1.08

0.00014

GO:0008094

ATP-dependent activity, acting on DNA

3 of 20

1.68

1.04

0.0072

GO:0140097

Catalytic activity, acting on DNA

5 of 92

1.24

1.02

0.0016

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:463

Mixed, incl. Mismatch repair, and Exodeoxyribonuclease III activity

6 of 17

2.05

3.57

1.35e-08

CL:4899

Mixed, incl. Peptidase M42, and ABC transporter, BtuC-like

4 of 5

2.4

3.06

1.24e-06

CL:484

DNA-directed DNA polymerase activity, and Exodeoxyribonuclease III activity

2 of 6

2.02

0.89

0.0209

CL:465

Mixed, incl. Single-stranded DNA binding, and DEAD/DEAH box helicase domain

2 of 7

1.96

0.85

0.0241

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

alus03430

Mismatch repair

4 of 14

1.96

2.29

1.56e-05

alus03420

Nucleotide excision repair

2 of 8

1.9

0.89

0.0197

alus03030

DNA replication

2 of 11

1.76

0.84

0.0226

alus03440

Homologous recombination

2 of 20

1.5

0.64

0.0495

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032300

Mismatch repair complex

2 of 2

2.5

1.03

0.0129

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0239

DNA-directed DNA polymerase

2 of 5

2.1

0.99

0.0138

KW-0234

DNA repair

3 of 25

1.58

0.89

0.0138

KW-0227

DNA damage

3 of 25

1.58

0.89

0.0138

KW-0235

DNA replication

2 of 15

1.63

0.75

0.0324

KW-0347

Helicase

2 of 19

1.52

0.67

0.0435

(more ...)

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