close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAX5B_020370Putative crossover junction endonuclease EME1 isoform 2. (578 aa)    
Predicted Functional Partners:
SMAX5B_007075
Putative crossover junction endonuclease MUS81.
   
 0.995
ENSSMAP00000003049
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).
    
 0.955
EME2
Putative crossover junction endonuclease EME2.
     
0.942
ENSSMAP00000027541
Exonuclease 1.
   
 0.917
SMAX5B_003026
Asparaginyl-tRNA synthetase cytoplasmic isoform 2.
    
 0.904
SLX1
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
    
 0.885
ENSSMAP00000007169
DNA replication helicase/nuclease 2.
   
 0.884
SMAX5B_020449
Putative DNA repair endonuclease XPF.
    
 0.882
SMAX5B_022127
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 0.876
SMAX5B_020824
DNA polymerase.
   
 0.836
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.