SMAX5B_012541 protein (Scophthalmus maximus)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

SMAX5B_012541

Putative liprin-beta-2-like. (676 aa)

Predicted Functional Partners:

ENSSMAP00000003095

0.900

SMAX5B_010616

0.768

SMAX5B_014351

0.768

SMAX5B_011205

0.768

PPFIA3

0.768

SMAX5B_002243

0.730

KAZN

0.730

SMAX5B_006394

0.418

PTPRD

0.418

PTPRD-2

0.418

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000003095	KAZN	ENSSMAP00000003095	ENSSMAP00000026488	annotation not available	Putative kazrin-like.	0.730
ENSSMAP00000003095	PPFIA3	ENSSMAP00000003095	ENSSMAP00000024933	annotation not available	Putative liprin-alpha-3-like.	0.730
ENSSMAP00000003095	SMAX5B_002243	ENSSMAP00000003095	ENSSMAP00000025653	annotation not available	Putative kazrin-like.	0.730
ENSSMAP00000003095	SMAX5B_010616	ENSSMAP00000003095	ENSSMAP00000007215	annotation not available	Putative liprin-alpha-2-like.	0.730
ENSSMAP00000003095	SMAX5B_011205	ENSSMAP00000003095	ENSSMAP00000012999	annotation not available	Putative liprin-alpha-3-like.	0.730
ENSSMAP00000003095	SMAX5B_012541	ENSSMAP00000003095	ENSSMAP00000003028	annotation not available	Putative liprin-beta-2-like.	0.900
ENSSMAP00000003095	SMAX5B_014351	ENSSMAP00000003095	ENSSMAP00000010114	annotation not available	Putative liprin-alpha-4.	0.730
KAZN	ENSSMAP00000003095	ENSSMAP00000026488	ENSSMAP00000003095	Putative kazrin-like.	annotation not available	0.730
KAZN	PTPRD	ENSSMAP00000026488	ENSSMAP00000016468	Putative kazrin-like.	Uncharacterized protein.	0.558
KAZN	PTPRD-2	ENSSMAP00000026488	ENSSMAP00000020929	Putative kazrin-like.	Putative receptor-type tyrosine-protein phosphatase delta isoform 2.	0.558
KAZN	SMAX5B_006394	ENSSMAP00000026488	ENSSMAP00000006109	Putative kazrin-like.	Protein-tyrosine-phosphatase.	0.558
KAZN	SMAX5B_012541	ENSSMAP00000026488	ENSSMAP00000003028	Putative kazrin-like.	Putative liprin-beta-2-like.	0.730
PPFIA3	ENSSMAP00000003095	ENSSMAP00000024933	ENSSMAP00000003095	Putative liprin-alpha-3-like.	annotation not available	0.730
PPFIA3	PTPRD	ENSSMAP00000024933	ENSSMAP00000016468	Putative liprin-alpha-3-like.	Uncharacterized protein.	0.646
PPFIA3	PTPRD-2	ENSSMAP00000024933	ENSSMAP00000020929	Putative liprin-alpha-3-like.	Putative receptor-type tyrosine-protein phosphatase delta isoform 2.	0.646
PPFIA3	SMAX5B_006394	ENSSMAP00000024933	ENSSMAP00000006109	Putative liprin-alpha-3-like.	Protein-tyrosine-phosphatase.	0.648
PPFIA3	SMAX5B_012541	ENSSMAP00000024933	ENSSMAP00000003028	Putative liprin-alpha-3-like.	Putative liprin-beta-2-like.	0.768
PTPRD	KAZN	ENSSMAP00000016468	ENSSMAP00000026488	Uncharacterized protein.	Putative kazrin-like.	0.558
PTPRD	PPFIA3	ENSSMAP00000016468	ENSSMAP00000024933	Uncharacterized protein.	Putative liprin-alpha-3-like.	0.646
PTPRD	SMAX5B_002243	ENSSMAP00000016468	ENSSMAP00000025653	Uncharacterized protein.	Putative kazrin-like.	0.558

page 1 of 4

Network Stats

number of nodes:

5

number of edges:

6

average node degree:

2.4

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.214

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051045

Negative regulation of membrane protein ectodomain proteolysis

4 of 5

3.57

6.73

4.23e-10

GO:0009725

Response to hormone

4 of 416

1.65

1.82

0.00033

GO:0034097

Response to cytokine

4 of 431

1.63

1.8

0.00035

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008191

Metalloendopeptidase inhibitor activity

4 of 13

3.16

6.05

2.64e-09

GO:0002020

Protease binding

4 of 73

2.41

3.98

7.50e-07

GO:0008270

Zinc ion binding

4 of 778

1.38

1.25

0.0021

GO:0046872

Metal ion binding

5 of 4369

0.73

0.43

0.0489

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

5 of 521

1.65

2.37

7.39e-06

GO:0005576

Extracellular region

5 of 2032

1.06

0.9

0.0022

GO:0005615

Extracellular space

4 of 1283

1.16

0.82

0.0142

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23867

Hemopexin-like repeats, and P domain

5 of 35

2.82

6.9

5.91e-11

CL:23868

Hemopexin-like repeats, and Protease inhibitor I35 (TIMP)

4 of 29

2.81

5.38

1.42e-08

CL:23874

Peptidoglycan binding-like, and Protease inhibitor I35 (TIMP)

3 of 15

2.97

3.92

2.83e-06

CL:23876

Peptidase M10A, cysteine switch, zinc binding site, and Tissue inhibitor of metalloproteinase, conserved site

2 of 10

2.97

2.04

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1592389

Activation of Matrix Metalloproteinases

3 of 57

2.39

2.42

0.00027

MAP-1474228

Degradation of the extracellular matrix

3 of 198

1.85

1.43

0.0052

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000088

Cardiovascular system

3 of 531

1.42

1.39

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0964

Secreted

4 of 281

1.82

2.42

3.67e-05

KW-1015

Disulfide bond

5 of 1389

1.22

1.31

0.00013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027465

Proteinase inhibitor I35b (TIMP), C-terminal

4 of 4

3.67

6.95

2.16e-10

IPR001820

Protease inhibitor I35 (TIMP)

4 of 4

3.67

6.95

2.16e-10

IPR030490

Tissue inhibitor of metalloproteinase, conserved site

3 of 3

3.67

4.94

1.44e-07

IPR001134

Netrin domain

4 of 33

2.75

4.9

6.79e-08

IPR008993

Tissue inhibitor of metalloproteinases-like, OB-fold

4 of 34

2.74

4.89

6.79e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00206

Tissue inhibitor of metalloproteinase family.

4 of 4

3.67

7.64

2.29e-11

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