SMAX5B_018085 protein (Scophthalmus maximus)

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SMAX5B_018085

Putative arachidonate 5-lipoxygenase. (674 aa)

Predicted Functional Partners:

CYP4F8

0.863

SMAX5B_001575

0.852

SMAX5B_011444

0.842

SMAX5B_022502

0.842

SMAX5B_012283

0.839

SMAX5B_022419

0.838

SMAX5B_022534

0.838

ENSSMAP00000014247

0.836

SMAX5B_011561

0.835

SMAX5B_009418

0.833

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP4F8	ENSSMAP00000014247	ENSSMAP00000019616	ENSSMAP00000014247	Cytochrome P450.	Phospholipase A2, group XIIB.	0.842
CYP4F8	SMAX5B_001575	ENSSMAP00000019616	ENSSMAP00000017928	Cytochrome P450.	Group XIIB secretory phospholipase A2-like protein isoform 2.	0.863
CYP4F8	SMAX5B_009418	ENSSMAP00000019616	ENSSMAP00000029413	Cytochrome P450.	Retinoic acid receptor responder 3 isoform 2.	0.865
CYP4F8	SMAX5B_011444	ENSSMAP00000019616	ENSSMAP00000011244	Cytochrome P450.	Putative cytochrome P450 2U1; Belongs to the cytochrome P450 family.	0.906
CYP4F8	SMAX5B_011561	ENSSMAP00000019616	ENSSMAP00000011043	Cytochrome P450.	Group XIIA secretory phospholipase A2 isoform 2.	0.842
CYP4F8	SMAX5B_012283	ENSSMAP00000019616	ENSSMAP00000018433	Cytochrome P450.	Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family.	0.868
CYP4F8	SMAX5B_018085	ENSSMAP00000019616	ENSSMAP00000003744	Cytochrome P450.	Putative arachidonate 5-lipoxygenase.	0.863
CYP4F8	SMAX5B_022419	ENSSMAP00000019616	ENSSMAP00000033985	Cytochrome P450.	Phospholipase A2.	0.856
CYP4F8	SMAX5B_022502	ENSSMAP00000019616	ENSSMAP00000012688	Cytochrome P450.	Putative cytochrome P450 2J6-like; Belongs to the cytochrome P450 family.	0.896
CYP4F8	SMAX5B_022534	ENSSMAP00000019616	ENSSMAP00000033993	Cytochrome P450.	Cyclooxygenase-2b.	0.851
ENSSMAP00000014247	CYP4F8	ENSSMAP00000014247	ENSSMAP00000019616	Phospholipase A2, group XIIB.	Cytochrome P450.	0.842
ENSSMAP00000014247	SMAX5B_001575	ENSSMAP00000014247	ENSSMAP00000017928	Phospholipase A2, group XIIB.	Group XIIB secretory phospholipase A2-like protein isoform 2.	0.845
ENSSMAP00000014247	SMAX5B_009418	ENSSMAP00000014247	ENSSMAP00000029413	Phospholipase A2, group XIIB.	Retinoic acid receptor responder 3 isoform 2.	0.871
ENSSMAP00000014247	SMAX5B_011561	ENSSMAP00000014247	ENSSMAP00000011043	Phospholipase A2, group XIIB.	Group XIIA secretory phospholipase A2 isoform 2.	0.844
ENSSMAP00000014247	SMAX5B_018085	ENSSMAP00000014247	ENSSMAP00000003744	Phospholipase A2, group XIIB.	Putative arachidonate 5-lipoxygenase.	0.836
ENSSMAP00000014247	SMAX5B_022419	ENSSMAP00000014247	ENSSMAP00000033985	Phospholipase A2, group XIIB.	Phospholipase A2.	0.864
ENSSMAP00000014247	SMAX5B_022534	ENSSMAP00000014247	ENSSMAP00000033993	Phospholipase A2, group XIIB.	Cyclooxygenase-2b.	0.859
SMAX5B_001575	CYP4F8	ENSSMAP00000017928	ENSSMAP00000019616	Group XIIB secretory phospholipase A2-like protein isoform 2.	Cytochrome P450.	0.863
SMAX5B_001575	ENSSMAP00000014247	ENSSMAP00000017928	ENSSMAP00000014247	Group XIIB secretory phospholipase A2-like protein isoform 2.	Phospholipase A2, group XIIB.	0.845
SMAX5B_001575	SMAX5B_009418	ENSSMAP00000017928	ENSSMAP00000029413	Group XIIB secretory phospholipase A2-like protein isoform 2.	Retinoic acid receptor responder 3 isoform 2.	0.860

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

8.69e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

10 of 21

2.61

9.97

1.28e-21

GO:0019693

Ribose phosphate metabolic process

11 of 126

1.87

5.58

1.03e-18

GO:0006006

Glucose metabolic process

4 of 20

2.23

3.0

1.01e-06

GO:0005975

Carbohydrate metabolic process

11 of 363

1.41

2.75

5.19e-14

GO:0006094

Gluconeogenesis

3 of 9

2.45

2.47

2.12e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 6

2.75

3.48

3.37e-07

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 11

2.36

1.93

0.00023

GO:0004807

Triose-phosphate isomerase activity

2 of 2

2.93

1.56

0.0015

GO:0016829

Lyase activity

5 of 177

1.38

1.31

0.00035

GO:0016853

Isomerase activity

4 of 98

1.54

1.29

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10783

Glycolytic process, and Glucoamylase

10 of 18

2.67

10.54

1.79e-22

CL:10787

Glycolytic process

9 of 13

2.77

10.09

7.88e-21

CL:10790

Gluconeogenesis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

4 of 5

2.83

4.1

2.46e-08

CL:10803

Fructose-bisphosphate aldolase activity, and Tetratricopeptide repeat

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 82

1.97

5.32

4.44e-15

map00680

Methane metabolism

5 of 39

2.04

3.41

3.19e-08

map01200

Carbon metabolism

9 of 192

1.6

3.29

3.41e-12

map01230

Biosynthesis of amino acids

8 of 230

1.47

2.49

1.26e-09

map00051

Fructose and mannose metabolism

4 of 70

1.68

1.96

2.52e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

6 of 23

2.34

4.71

2.22e-10

MAP-70326

Glucose metabolism

6 of 107

1.68

2.43

5.68e-07

MAP-70263

Gluconeogenesis

5 of 91

1.67

2.02

1.42e-05

MAP-71387

Metabolism of carbohydrates

6 of 235

1.33

1.51

2.70e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 13

2.51

4.51

1.63e-09

KW-0312

Gluconeogenesis

3 of 3

2.93

3.02

2.97e-06

KW-0413

Isomerase

3 of 48

1.72

1.29

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00121

Triosephosphate isomerase

2 of 2

2.93

1.18

0.0074

PF01116

Fructose-bisphosphate aldolase class-II

2 of 3

2.75

1.17

0.0074

PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

2 of 6

2.45

1.06

0.0114

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 9

2.27

0.96

0.0168

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 73

1.67

1.15

0.0038

IPR035990

Triosephosphate isomerase superfamily

2 of 2

2.93

1.1

0.0105

IPR000652

Triosephosphate isomerase

2 of 2

2.93

1.1

0.0105

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 3

2.75

1.09

0.0105

IPR029154

3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain

2 of 6

2.45

0.94

0.0195

(more ...)

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