OTUB2 protein (Scophthalmus maximus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

OTUB2

Putative ubiquitin thioesterase OTUB2 isoform 2. (237 aa)

Predicted Functional Partners:

SMAX5B_007767

0.869

SMAX5B_009815

0.869

TRAF6

0.850

SMAX5B_001446

0.827

SMAX5B_021798

0.795

SMAX5B_005524

0.795

SMAX5B_015354

0.774

SMAX5B_016719

0.764

SMAX5B_010547

0.758

SMAX5B_012422

0.740

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OTUB2	SMAX5B_001446	ENSSMAP00000004487	ENSSMAP00000015064	Putative ubiquitin thioesterase OTUB2 isoform 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.827
OTUB2	SMAX5B_005524	ENSSMAP00000004487	ENSSMAP00000034591	Putative ubiquitin thioesterase OTUB2 isoform 2.	Putative TNF receptor-associated factor 5-like.	0.795
OTUB2	SMAX5B_007767	ENSSMAP00000004487	ENSSMAP00000000412	Putative ubiquitin thioesterase OTUB2 isoform 2.	Putative ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family.	0.869
OTUB2	SMAX5B_009815	ENSSMAP00000004487	ENSSMAP00000011479	Putative ubiquitin thioesterase OTUB2 isoform 2.	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.869
OTUB2	SMAX5B_010547	ENSSMAP00000004487	ENSSMAP00000007101	Putative ubiquitin thioesterase OTUB2 isoform 2.	Putative forkhead box protein M1.	0.758
OTUB2	SMAX5B_012422	ENSSMAP00000004487	ENSSMAP00000023242	Putative ubiquitin thioesterase OTUB2 isoform 2.	Putative ubiquitin carboxyl-terminal hydrolase 8 isoform 2; Belongs to the peptidase C19 family.	0.740
OTUB2	SMAX5B_015354	ENSSMAP00000004487	ENSSMAP00000024814	Putative ubiquitin thioesterase OTUB2 isoform 2.	Putative cystine/glutamate transporter.	0.774
OTUB2	SMAX5B_016719	ENSSMAP00000004487	ENSSMAP00000005569	Putative ubiquitin thioesterase OTUB2 isoform 2.	Putative WASH complex subunit CCDC53 isoform 2.	0.764
OTUB2	SMAX5B_021798	ENSSMAP00000004487	ENSSMAP00000004478	Putative ubiquitin thioesterase OTUB2 isoform 2.	Putative TNF receptor-associated factor 3.	0.795
OTUB2	TRAF6	ENSSMAP00000004487	ENSSMAP00000014624	Putative ubiquitin thioesterase OTUB2 isoform 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.850
SMAX5B_001446	OTUB2	ENSSMAP00000015064	ENSSMAP00000004487	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Putative ubiquitin thioesterase OTUB2 isoform 2.	0.827
SMAX5B_001446	SMAX5B_007767	ENSSMAP00000015064	ENSSMAP00000000412	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Putative ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family.	0.816
SMAX5B_001446	SMAX5B_009815	ENSSMAP00000015064	ENSSMAP00000011479	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.816
SMAX5B_001446	SMAX5B_010547	ENSSMAP00000015064	ENSSMAP00000007101	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Putative forkhead box protein M1.	0.700
SMAX5B_001446	SMAX5B_015354	ENSSMAP00000015064	ENSSMAP00000024814	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Putative cystine/glutamate transporter.	0.618
SMAX5B_001446	TRAF6	ENSSMAP00000015064	ENSSMAP00000014624	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.678
SMAX5B_005524	OTUB2	ENSSMAP00000034591	ENSSMAP00000004487	Putative TNF receptor-associated factor 5-like.	Putative ubiquitin thioesterase OTUB2 isoform 2.	0.795
SMAX5B_005524	SMAX5B_007767	ENSSMAP00000034591	ENSSMAP00000000412	Putative TNF receptor-associated factor 5-like.	Putative ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family.	0.761
SMAX5B_005524	SMAX5B_009815	ENSSMAP00000034591	ENSSMAP00000011479	Putative TNF receptor-associated factor 5-like.	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.761
SMAX5B_005524	SMAX5B_012422	ENSSMAP00000034591	ENSSMAP00000023242	Putative TNF receptor-associated factor 5-like.	Putative ubiquitin carboxyl-terminal hydrolase 8 isoform 2; Belongs to the peptidase C19 family.	0.468