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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EIF2C3-2Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (860 aa)    
Predicted Functional Partners:
SMAX5B_007646
Endoribonuclease dicer-like protein; Belongs to the helicase family. Dicer subfamily.
   
 0.954
TARBP2
RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]
    
 0.919
SMAX5B_020221
Putative trinucleotide repeat-containing 6B protein-like.
    
 0.891
SMAX5B_018492
Putative interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 2.
    
 0.879
SMAX5B_005937
Putative trinucleotide repeat-containing 6A protein.
    
 0.872
SMAX5B_020852
Putative trinucleotide repeat-containing 6C protein-like.
    
 0.872
SMAX5B_007391
Putative trinucleotide repeat-containing 6C protein-like.
    
 0.872
SMAX5B_001220
Putative ribonuclease 3.
   
 0.855
SMAX5B_006402
Putative mitochondrial fission factor-like A-like.
   
 0.815
SMAX5B_010205
Putative 39S ribosomal protein L44 mitochondrial.
   
 0.815
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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