close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAX5B_007371Complement component C3 isoform 3. (1658 aa)    
Predicted Functional Partners:
SMAX5B_004497
Putative complement factor I; Belongs to the peptidase S1 family.
   
 0.923
SMAX5B_005581
C4b-binding protein alpha chain.
   
 0.879
SMAX5B_015239
Putative complement C5; Belongs to the UDP-glycosyltransferase family.
   
0.866
SMAX5B_001246
E3 ubiquitin-protein ligase RING2.
    
 0.852
SMAX5B_000212
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 0.847
SMAX5B_012036
Putative complement C1r-A subcomponent-like isoform 2; Belongs to the peptidase S1 family.
   
 0.832
ENSSMAP00000016567
annotation not available
   
 0.829
SMAX5B_000611
Uncharacterized protein; Belongs to the peptidase S1 family.
   
 0.828
SMAX5B_017182
Putative mannan-binding lectin serine protease 1; Belongs to the peptidase S1 family.
   
 0.822
SMAX5B_011772
Putative complement C1s subcomponent-like; Belongs to the peptidase S1 family.
   
 0.822
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
Server load: low (36%) [HD]