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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAX5B_008861Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (510 aa)    
Predicted Functional Partners:
SMAX5B_016703
Putative E3 SUMO-protein ligase EGR2.
  
0.906
SMAX5B_019619
Putative adenylate kinase 9 isoform 2.
    
  0.873
SMAX5B_020741
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.871
SMAX5B_019358
Mitogen-activated protein kinase.
   
 0.871
SMAX5B_007434
Putative CREB-binding protein-like.
    
 0.861
SMAX5B_020700
Putative CREB-binding protein-like.
    
 0.861
SMAX5B_006291
Putative histone acetyltransferase p300-like isoform 2.
    
 0.855
SMAX5B_020257
Putative histone acetyltransferase p300-like.
    
 0.855
SMAX5B_002836
Proto-oncogene protein c-Fos.
   
 0.846
SMAX5B_017761
Putative E3 SUMO-protein ligase EGR2-like.
    
 
0.829
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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