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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSSMAP00000007169DNA replication helicase/nuclease 2. (1374 aa)    
Predicted Functional Partners:
SMAX5B_016122
Putative WD repeat and HMG-box DNA-binding protein 1.
   
 
 0.995
SMAX5B_011057
Putative ankyrin repeat domain-containing protein 32.
   
 0.994
ENSSMAP00000027541
Exonuclease 1.
   
 0.986
SMAX5B_009864
Putative replication protein A 70 kDa DNA-binding subunit.
    
 0.976
RPA1
Replication protein A1.
    
 0.976
ENSSMAP00000001780
BLM RecQ like helicase.
   
 0.973
ENSSMAP00000008138
RecQ helicase-like 4.
   
 0.965
SMAX5B_006294
Putative flap endonuclease 1-like.
   
 0.961
SMAX5B_020184
Putative meiosis-specific with OB domain-containing protein.
    
 0.961
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.961
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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