STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAX5B_019386Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)    
Predicted Functional Partners:
SMAX5B_008515
Fibroblast growth factor receptor.
    
 0.971
SMAX5B_010866
Fibroblast growth factor receptor.
    
 0.961
SMAX5B_003034
Fibroblast growth factor receptor.
    
 0.956
SMAX5B_008930
Fibroblast growth factor receptor.
    
 0.940
SMAX5B_004134
Receptor protein-tyrosine kinase.
    
 0.940
SMAX5B_008851
Putative platelet-derived growth factor receptor beta.
   
 0.896
ENSSMAP00000023979
annotation not available
   
 0.891
SMAX5B_022303
Putative tyrosine-protein kinase receptor Tie-1.
    
 0.890
SMAX5B_008854
Tyrosine-protein kinase receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
   
 0.885
ENSSMAP00000023223
Platelet-derived growth factor receptor, alpha polypeptide.
   
 0.885
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.