close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1L1Putative Niemann-Pick C1-like protein 1. (1357 aa)    
Predicted Functional Partners:
SMAX5B_000402
Epididymal secretory protein E1 isoform 2.
   
 0.985
SMAX5B_006678
Putative sterol regulatory element-binding protein 2-like.
   
 0.925
SMAX5B_020881
Sterol regulatory element-binding protein 1.
   
 0.923
SMAX5B_019681
Putative N-myc proto-oncogene protein.
   
 0.907
SMAX5B_010023
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.827
OSBPL8
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.827
SMAX5B_004683
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
   
 0.819
SMAX5B_021651
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
   
 0.815
SMAX5B_015402
Putative membrane-bound transcription factor site-1 protease.
   
 
 0.645
SMAX5B_022318
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.625
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
Server load: low (30%) [HD]