SMAX5B_008006 protein (Scophthalmus maximus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SMAX5B_008006

Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)

Predicted Functional Partners:

SMAX5B_012084

0.768

SMAX5B_004119

0.661

SMAX5B_013959

0.661

SMAX5B_016752

0.661

SMAX5B_001777

0.656

SMAX5B_013819

0.641

SMAX5B_009437

0.632

SMAX5B_014065

0.541

SMAX5B_014860

0.521

GET1

0.497

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GET1	SMAX5B_004119	ENSSMAP00000006056	ENSSMAP00000012764	Tryptophan-rich protein.	Uncharacterized protein.	0.672
GET1	SMAX5B_008006	ENSSMAP00000006056	ENSSMAP00000008750	Tryptophan-rich protein.	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	0.497
GET1	SMAX5B_009437	ENSSMAP00000006056	ENSSMAP00000028299	Tryptophan-rich protein.	Syntaxin 5A isoform 2; Belongs to the PDGF/VEGF growth factor family.	0.606
GET1	SMAX5B_012084	ENSSMAP00000006056	ENSSMAP00000031141	Tryptophan-rich protein.	Uncharacterized protein.	0.815
GET1	SMAX5B_013819	ENSSMAP00000006056	ENSSMAP00000016941	Tryptophan-rich protein.	Putative tetratricopeptide repeat protein 33.	0.633
GET1	SMAX5B_013959	ENSSMAP00000006056	ENSSMAP00000019448	Tryptophan-rich protein.	Putative small glutamine-rich tetratricopeptide repeat-containing protein beta.	0.672
GET1	SMAX5B_016752	ENSSMAP00000006056	ENSSMAP00000027765	Tryptophan-rich protein.	Putative small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2.	0.672
SMAX5B_001777	SMAX5B_008006	ENSSMAP00000030590	ENSSMAP00000008750	Protein transport protein Sec61 subunit gamma.	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	0.656
SMAX5B_001777	SMAX5B_012084	ENSSMAP00000030590	ENSSMAP00000031141	Protein transport protein Sec61 subunit gamma.	Uncharacterized protein.	0.999
SMAX5B_004119	GET1	ENSSMAP00000012764	ENSSMAP00000006056	Uncharacterized protein.	Tryptophan-rich protein.	0.672
SMAX5B_004119	SMAX5B_008006	ENSSMAP00000012764	ENSSMAP00000008750	Uncharacterized protein.	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	0.661
SMAX5B_004119	SMAX5B_009437	ENSSMAP00000012764	ENSSMAP00000028299	Uncharacterized protein.	Syntaxin 5A isoform 2; Belongs to the PDGF/VEGF growth factor family.	0.755
SMAX5B_004119	SMAX5B_012084	ENSSMAP00000012764	ENSSMAP00000031141	Uncharacterized protein.	Uncharacterized protein.	0.801
SMAX5B_008006	GET1	ENSSMAP00000008750	ENSSMAP00000006056	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	Tryptophan-rich protein.	0.497
SMAX5B_008006	SMAX5B_001777	ENSSMAP00000008750	ENSSMAP00000030590	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	Protein transport protein Sec61 subunit gamma.	0.656
SMAX5B_008006	SMAX5B_004119	ENSSMAP00000008750	ENSSMAP00000012764	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	Uncharacterized protein.	0.661
SMAX5B_008006	SMAX5B_009437	ENSSMAP00000008750	ENSSMAP00000028299	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	Syntaxin 5A isoform 2; Belongs to the PDGF/VEGF growth factor family.	0.632
SMAX5B_008006	SMAX5B_012084	ENSSMAP00000008750	ENSSMAP00000031141	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	Uncharacterized protein.	0.768
SMAX5B_008006	SMAX5B_013819	ENSSMAP00000008750	ENSSMAP00000016941	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	Putative tetratricopeptide repeat protein 33.	0.641
SMAX5B_008006	SMAX5B_013959	ENSSMAP00000008750	ENSSMAP00000019448	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.	Putative small glutamine-rich tetratricopeptide repeat-containing protein beta.	0.661

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.881

expected number of edges:

10

PPI enrichment p-value:

0.00417

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2001013

Epithelial cell proliferation involved in renal tubule morphogenesis

2 of 4

2.97

0.73

0.0493

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016500

Protein-hormone receptor activity

3 of 16

2.55

1.86

0.00037

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:34708

Mixed, incl. Relaxin receptors, and Regulation of FZD by ubiquitination

8 of 30

2.7

8.24

4.53e-17

CL:34709

Relaxin receptors, and Regulation of FZD by ubiquitination

4 of 20

2.57

3.32

5.27e-07

CL:34735

Relaxin receptors

2 of 5

2.87

1.28

0.0049

CL:34715

Regulation of FZD by ubiquitination

2 of 6

2.8

1.25

0.0055

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-444821

Relaxin receptors

2 of 8

2.67

0.94

0.0199

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00082

Subtilase family

2 of 9

2.62

0.82

0.0324

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00013

Leucine rich repeat N-terminal domain

4 of 90

1.92

1.93

0.00010

SM00369

Leucine-rich repeats, typical (most populated) subfamily

4 of 122

1.79

1.75

0.00017

SM00370

Leucine-rich repeats, outliers

4 of 211

1.55

1.32

0.00094

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