STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN1CPutative cyclin-dependent kinase inhibitor 1C-like. (216 aa)    
Predicted Functional Partners:
SMAX5B_002958
Putative S-phase kinase-associated protein 2.
    
 0.974
SMAX5B_003201
Putative G1/S-specific cyclin-E1; Belongs to the cyclin family.
   
 0.961
SMAX5B_009686
Cullin-1; Belongs to the cullin family.
    
 0.956
SMAX5B_005314
Putative G1/S-specific cyclin-E2-like; Belongs to the cyclin family.
   
 0.956
CCNE2
Putative G1/S-specific cyclin-E2-like isoform 2; Belongs to the cyclin family.
   
 0.956
ENSSMAP00000005308
Cyclin A1.
    
 0.952
SMAX5B_014334
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.952
SMAX5B_004110
S-phase kinase-associated protein 1-like protein; Belongs to the SKP1 family.
    
 0.952
SMAX5B_018936
Putative cyclin-A2; Belongs to the cyclin family.
    
 0.952
SMAX5B_001446
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.952
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.