STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAX5B_006077DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (706 aa)    
Predicted Functional Partners:
SMAX5B_016507
Putative recQ-mediated genome instability protein 1.
    
 0.999
SMAX5B_000328
Putative Fanconi anemia group M protein.
   
 0.999
ENSSMAP00000001780
BLM RecQ like helicase.
  
 0.998
ENSSMAP00000028620
Replication protein A3.
    
 0.994
ENSSMAP00000008138
RecQ helicase-like 4.
  
 0.991
SMAX5B_005621
Putative tudor domain-containing protein 3 isoform 2.
    
 0.989
SMAX5B_020449
Putative DNA repair endonuclease XPF.
    
 0.988
SMAX5B_008566
Putative recQ-mediated genome instability protein 2.
    
 0.987
SMAX5B_009864
Putative replication protein A 70 kDa DNA-binding subunit.
  
 0.987
RPA1
Replication protein A1.
  
 0.987
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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