SMAX5B_018659 protein (Scophthalmus maximus)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SMAX5B_018659

RALB protein. (207 aa)

Predicted Functional Partners:

SMAX5B_006274

0.967

SMAX5B_002937

0.963

SMAX5B_012637

0.898

SMAX5B_008282

0.898

SMAX5B_007736

0.893

SMAX5B_021325

0.890

SMAX5B_010933

0.886

SMAX5B_005409

0.878

SMAX5B_008891

0.876

SMAX5B_000093

0.876

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SMAX5B_000093	SMAX5B_018659	ENSSMAP00000007430	ENSSMAP00000010672	Putative afadin.	RALB protein.	0.876
SMAX5B_002937	SMAX5B_006274	ENSSMAP00000028700	ENSSMAP00000021208	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	RalA-binding protein 1.	0.513
SMAX5B_002937	SMAX5B_007736	ENSSMAP00000028700	ENSSMAP00000001266	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Putative exocyst complex component 4.	0.999
SMAX5B_002937	SMAX5B_008282	ENSSMAP00000028700	ENSSMAP00000016418	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Putative intersectin-2.	0.421
SMAX5B_002937	SMAX5B_012637	ENSSMAP00000028700	ENSSMAP00000008708	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Putative intersectin-2.	0.421
SMAX5B_002937	SMAX5B_018659	ENSSMAP00000028700	ENSSMAP00000010672	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	RALB protein.	0.963
SMAX5B_005409	SMAX5B_018659	ENSSMAP00000032617	ENSSMAP00000010672	Putative dedicator of cytokinesis protein 4-like; Belongs to the DOCK family.	RALB protein.	0.878
SMAX5B_006274	SMAX5B_002937	ENSSMAP00000021208	ENSSMAP00000028700	RalA-binding protein 1.	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	0.513
SMAX5B_006274	SMAX5B_010933	ENSSMAP00000021208	ENSSMAP00000014837	RalA-binding protein 1.	Putative ras GTPase-activating protein 1 isoform 4.	0.473
SMAX5B_006274	SMAX5B_018659	ENSSMAP00000021208	ENSSMAP00000010672	RalA-binding protein 1.	RALB protein.	0.967
SMAX5B_007736	SMAX5B_002937	ENSSMAP00000001266	ENSSMAP00000028700	Putative exocyst complex component 4.	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	0.999
SMAX5B_007736	SMAX5B_018659	ENSSMAP00000001266	ENSSMAP00000010672	Putative exocyst complex component 4.	RALB protein.	0.893
SMAX5B_008282	SMAX5B_002937	ENSSMAP00000016418	ENSSMAP00000028700	Putative intersectin-2.	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	0.421
SMAX5B_008282	SMAX5B_012637	ENSSMAP00000016418	ENSSMAP00000008708	Putative intersectin-2.	Putative intersectin-2.	0.987
SMAX5B_008282	SMAX5B_018659	ENSSMAP00000016418	ENSSMAP00000010672	Putative intersectin-2.	RALB protein.	0.898
SMAX5B_008891	SMAX5B_018659	ENSSMAP00000005505	ENSSMAP00000010672	Mitogen-activated protein kinase.	RALB protein.	0.876
SMAX5B_010933	SMAX5B_006274	ENSSMAP00000014837	ENSSMAP00000021208	Putative ras GTPase-activating protein 1 isoform 4.	RalA-binding protein 1.	0.473
SMAX5B_010933	SMAX5B_018659	ENSSMAP00000014837	ENSSMAP00000010672	Putative ras GTPase-activating protein 1 isoform 4.	RALB protein.	0.886
SMAX5B_010933	SMAX5B_021325	ENSSMAP00000014837	ENSSMAP00000022394	Putative ras GTPase-activating protein 1 isoform 4.	Putative neurofibromin.	0.847
SMAX5B_012637	SMAX5B_002937	ENSSMAP00000008708	ENSSMAP00000028700	Putative intersectin-2.	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	0.421

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.927

expected number of edges:

11

PPI enrichment p-value:

1.65e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006032

Chitin catabolic process

3 of 46

2.17

1.91

0.0013

GO:0005975

Carbohydrate metabolic process

5 of 391

1.47

1.67

0.00017

GO:0000272

Polysaccharide catabolic process

3 of 132

1.72

1.37

0.0051

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 189

1.78

2.82

2.09e-06

GO:0004568

Chitinase activity

3 of 38

2.26

2.41

0.00022

GO:0008061

Chitin binding

3 of 49

2.15

2.24

0.00034

GO:0102148

N-acetyl-beta-D-galactosaminidase activity

2 of 8

2.76

1.89

0.0022

GO:0004563

beta-N-acetylhexosaminidase activity

2 of 8

2.76

1.89

0.0022

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

5 of 432

1.42

1.7

6.50e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21184821

(2011) Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NCNga mice.

2 of 7

2.82

2.05

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16527

Glycosyl hydrolases family 18, and beta-Lactam resistance

5 of 15

2.88

7.31

1.73e-11

CL:16544

Glycosyl hydrolases family 18

3 of 6

3.06

4.43

5.55e-07

CL:16530

beta-Lactam resistance, and Beta-acetyl hexosaminidase like

2 of 5

2.96

2.36

0.00049

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

5 of 177

1.81

3.25

1.49e-07

map00604

Glycosphingolipid biosynthesis - ganglio series

2 of 13

2.55

2.04

0.0012

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

2 of 19

2.38

1.92

0.0016

map00511

Other glycan degradation

2 of 22

2.32

1.9

0.0016

map00531

Glycosaminoglycan degradation

2 of 29

2.2

1.78

0.0022

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2160916

Hyaluronan uptake and degradation

2 of 9

2.71

1.56

0.0065

MAP-2024101

CS/DS degradation

2 of 8

2.76

1.56

0.0065

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

2 of 8

2.76

1.56

0.0065

MAP-2022857

Keratan sulfate degradation

2 of 13

2.55

1.54

0.0065

MAP-1638074

Keratan sulfate/keratin metabolism

2 of 13

2.55

1.54

0.0065

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009277

Fungal-type cell wall

3 of 48

2.16

2.03

0.00081

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 72

2.1

3.37

2.15e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00704

Glycosyl hydrolases family 18

3 of 13

2.72

3.23

2.32e-05

PF14845

Beta-acetyl hexosaminidase like

2 of 3

3.18

2.23

0.00079

PF00728

Glycosyl hydrolase family 20, catalytic domain

2 of 9

2.71

1.8

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017853

Glycoside hydrolase superfamily

5 of 117

1.99

3.53

3.60e-07

IPR001223

Glycoside hydrolase family 18, catalytic domain

3 of 29

2.37

2.4

0.00028

IPR029019

Beta-hexosaminidase, eukaryotic type, N-terminal

2 of 3

3.18

2.05

0.0014

IPR025705

Beta-hexosaminidase

2 of 9

2.71

1.58

0.0060

IPR015883

Glycoside hydrolase family 20, catalytic domain

2 of 9

2.71

1.58

0.0060

(more ...)

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