STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAX5B_011536Putative cyclin-dependent kinase 4 inhibitor B-like. (332 aa)    
Predicted Functional Partners:
SMAX5B_019272
Putative E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
  
 0.991
SMAX5B_001446
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.978
SMAX5B_014374
RanBP2-type domain-containing protein.
  
 0.965
SMAX5B_014088
Putative cyclin-dependent kinase 4 isoform 2; Belongs to the protein kinase superfamily.
    
 0.957
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
 0.948
SMAX5B_010579
Putative G1/S-specific cyclin-D2; Belongs to the cyclin family.
    
 0.914
SMAX5B_017843
Putative G1/S-specific cyclin-D2-like; Belongs to the cyclin family.
    
 0.914
SMAX5B_014334
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
    
 0.913
SMAX5B_008692
Cyclin-dependent kinase 1 isoform 2; Belongs to the protein kinase superfamily.
    
 0.913
SMAX5B_007150
Putative G1/S-specific cyclin-D1; Belongs to the cyclin family.
    
 0.901
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.