SMAX5B_019005 protein (Scophthalmus maximus)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SMAX5B_019005

Putative RING finger protein 44. (440 aa)

Predicted Functional Partners:

ENSSMAP00000008002

0.916

ENSSMAP00000034351

0.886

ENSSMAP00000000415

0.820

ENSSMAP00000014581

0.820

ENSSMAP00000014631

0.800

SMAX5B_008875

0.752

SMAX5B_007516

0.752

SMAX5B_006457

0.664

SMAX5B_019161

0.641

SMAX5B_013883

0.640

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000000415	ENSSMAP00000008002	ENSSMAP00000000415	ENSSMAP00000008002	annotation not available	Ribosomal protein S27a.	0.984
ENSSMAP00000000415	ENSSMAP00000014581	ENSSMAP00000000415	ENSSMAP00000014581	annotation not available	annotation not available	0.801
ENSSMAP00000000415	ENSSMAP00000014631	ENSSMAP00000000415	ENSSMAP00000014631	annotation not available	annotation not available	0.975
ENSSMAP00000000415	ENSSMAP00000034351	ENSSMAP00000000415	ENSSMAP00000034351	annotation not available	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.997
ENSSMAP00000000415	SMAX5B_006457	ENSSMAP00000000415	ENSSMAP00000031659	annotation not available	Ubiquitin-conjugating enzyme E2 variant 2.	0.975
ENSSMAP00000000415	SMAX5B_007516	ENSSMAP00000000415	ENSSMAP00000017168	annotation not available	Ube2k protein; Belongs to the ubiquitin-conjugating enzyme family.	0.949
ENSSMAP00000000415	SMAX5B_008875	ENSSMAP00000000415	ENSSMAP00000003125	annotation not available	Ube2k protein; Belongs to the ubiquitin-conjugating enzyme family.	0.949
ENSSMAP00000000415	SMAX5B_013883	ENSSMAP00000000415	ENSSMAP00000009444	annotation not available	Mothers against decapentaplegic homolog.	0.578
ENSSMAP00000000415	SMAX5B_019005	ENSSMAP00000000415	ENSSMAP00000014223	annotation not available	Putative RING finger protein 44.	0.820
ENSSMAP00000008002	ENSSMAP00000000415	ENSSMAP00000008002	ENSSMAP00000000415	Ribosomal protein S27a.	annotation not available	0.984
ENSSMAP00000008002	ENSSMAP00000014581	ENSSMAP00000008002	ENSSMAP00000014581	Ribosomal protein S27a.	annotation not available	0.984
ENSSMAP00000008002	ENSSMAP00000014631	ENSSMAP00000008002	ENSSMAP00000014631	Ribosomal protein S27a.	annotation not available	0.998
ENSSMAP00000008002	ENSSMAP00000034351	ENSSMAP00000008002	ENSSMAP00000034351	Ribosomal protein S27a.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.999
ENSSMAP00000008002	SMAX5B_006457	ENSSMAP00000008002	ENSSMAP00000031659	Ribosomal protein S27a.	Ubiquitin-conjugating enzyme E2 variant 2.	0.989
ENSSMAP00000008002	SMAX5B_007516	ENSSMAP00000008002	ENSSMAP00000017168	Ribosomal protein S27a.	Ube2k protein; Belongs to the ubiquitin-conjugating enzyme family.	0.970
ENSSMAP00000008002	SMAX5B_008875	ENSSMAP00000008002	ENSSMAP00000003125	Ribosomal protein S27a.	Ube2k protein; Belongs to the ubiquitin-conjugating enzyme family.	0.970
ENSSMAP00000008002	SMAX5B_013883	ENSSMAP00000008002	ENSSMAP00000009444	Ribosomal protein S27a.	Mothers against decapentaplegic homolog.	0.682
ENSSMAP00000008002	SMAX5B_019005	ENSSMAP00000008002	ENSSMAP00000014223	Ribosomal protein S27a.	Putative RING finger protein 44.	0.916
ENSSMAP00000014581	ENSSMAP00000000415	ENSSMAP00000014581	ENSSMAP00000000415	annotation not available	annotation not available	0.801
ENSSMAP00000014581	ENSSMAP00000008002	ENSSMAP00000014581	ENSSMAP00000008002	annotation not available	Ribosomal protein S27a.	0.984

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

5 of 35

2.34

3.36

2.46e-07

GO:0006354

DNA-templated transcription, elongation

4 of 26

2.37

2.56

1.23e-05

GO:0006283

Transcription-coupled nucleotide-excision repair

3 of 7

2.82

2.25

7.60e-05

GO:0006368

Transcription elongation from RNA polymerase II promoter

3 of 24

2.28

1.74

0.00050

GO:0009411

Response to UV

4 of 84

1.86

1.67

0.00034

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000993

RNA polymerase II complex binding

3 of 32

2.16

1.29

0.0036

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008023

Transcription elongation factor complex

4 of 44

2.14

2.31

2.55e-05

GO:0016593

Cdc73/Paf1 complex

2 of 7

2.64

1.49

0.0019

GO:0000109

Nucleotide-excision repair complex

2 of 6

2.71

1.49

0.0019

GO:0031464

Cul4A-RING E3 ubiquitin ligase complex

2 of 10

2.48

1.36

0.0031

GO:0016591

RNA polymerase II, holoenzyme

3 of 69

1.82

1.34

0.0019

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27507608

(2017) Cockayne syndrome: Clinical features, model systems and pathways.

4 of 8

2.88

2.87

5.56e-06

PMID:30753618

(2019) Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.

3 of 8

2.76

1.52

0.0017

PMID:32649862

(2020) A Genetic Map of the Response to DNA Damage in Human Cells.

4 of 50

2.09

1.44

0.0017

PMID:33007515

(2020) Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.

3 of 17

2.43

1.18

0.0067

PMID:36077479

(2022) Genome of Laudakia sacra Provides New Insights into High-Altitude Adaptation of Ectotherms.

3 of 34

2.13

0.78

0.0362

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7860

Nucleotide-excision repair factor 1 complex, and Double-strand break repair via classical nonhomologous end joining

3 of 5

2.96

2.39

4.45e-05

CL:9183

Mixed, incl. BAT3 complex binding, and Zinc finger, SIAH-type

2 of 5

2.79

1.1

0.0104

CL:7139

RNA Polymerase II Pre-transcription Events, and Mediator complex

3 of 121

1.58

0.67

0.0448

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gga03420

Nucleotide excision repair

5 of 35

2.34

4.14

4.50e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

GGA-6781823

Formation of TC-NER Pre-Incision Complex

3 of 38

2.08

1.28

0.0035

GGA-6782210

Gap-filling DNA repair synthesis and ligation in TC-NER

3 of 43

2.03

1.27

0.0035

GGA-6782135

Dual incision in TC-NER

3 of 46

2.0

1.27

0.0035

GGA-353303

Nucleotide Excision Repair

2 of 12

2.41

1.1

0.0094

GGA-73762

RNA Polymerase I Transcription Initiation

2 of 31

1.99

0.74

0.0404

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

3 of 37

2.09

1.53

0.0011

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.58

1.37

0.0031

GOCC:0016591

RNA polymerase II, holoenzyme

3 of 63

1.86

1.36

0.0018

GOCC:0000109

Nucleotide-excision repair complex

2 of 10

2.48

1.32

0.0037

GOCC:0031464

Cul4A-RING E3 ubiquitin ligase complex

2 of 11

2.44

1.31

0.0039

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

3 of 76

1.78

1.08

0.0068

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