ENSSMAP00000016265 protein (Scophthalmus maximus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ENSSMAP00000016265

Chondroadherin. (363 aa)

Predicted Functional Partners:

SMAX5B_020151

0.861

SMAX5B_015913

0.861

ENSSMAP00000020695

0.861

ENSSMAP00000004730

0.859

SMAX5B_007191

0.856

SMAX5B_010271

0.856

SMAX5B_012204

0.856

SMAX5B_010474

0.845

SMAX5B_013794

0.845

SMAX5B_020277

0.844

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000004730	ENSSMAP00000016265	ENSSMAP00000004730	ENSSMAP00000016265	Integrin, beta 1a.	Chondroadherin.	0.859
ENSSMAP00000004730	ENSSMAP00000020695	ENSSMAP00000004730	ENSSMAP00000020695	Integrin, beta 1a.	Integrin, beta 6.	0.840
ENSSMAP00000004730	SMAX5B_007191	ENSSMAP00000004730	ENSSMAP00000011466	Integrin, beta 1a.	Integrin beta; Belongs to the integrin beta chain family.	0.843
ENSSMAP00000004730	SMAX5B_010271	ENSSMAP00000004730	ENSSMAP00000019922	Integrin, beta 1a.	Integrin beta; Belongs to the integrin beta chain family.	0.626
ENSSMAP00000004730	SMAX5B_010474	ENSSMAP00000004730	ENSSMAP00000012689	Integrin, beta 1a.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.904
ENSSMAP00000004730	SMAX5B_012204	ENSSMAP00000004730	ENSSMAP00000026076	Integrin, beta 1a.	Putative integrin alpha-10; Belongs to the integrin alpha chain family.	0.904
ENSSMAP00000004730	SMAX5B_013794	ENSSMAP00000004730	ENSSMAP00000012752	Integrin, beta 1a.	Putative integrin alpha-1; Belongs to the integrin alpha chain family.	0.904
ENSSMAP00000004730	SMAX5B_015913	ENSSMAP00000004730	ENSSMAP00000018538	Integrin, beta 1a.	Integrin beta; Belongs to the integrin beta chain family.	0.637
ENSSMAP00000004730	SMAX5B_020151	ENSSMAP00000004730	ENSSMAP00000006080	Integrin, beta 1a.	Integrin beta.	0.573
ENSSMAP00000004730	SMAX5B_020277	ENSSMAP00000004730	ENSSMAP00000018492	Integrin, beta 1a.	Putative integrin alpha-3; Belongs to the integrin alpha chain family.	0.927
ENSSMAP00000016265	ENSSMAP00000004730	ENSSMAP00000016265	ENSSMAP00000004730	Chondroadherin.	Integrin, beta 1a.	0.859
ENSSMAP00000016265	ENSSMAP00000020695	ENSSMAP00000016265	ENSSMAP00000020695	Chondroadherin.	Integrin, beta 6.	0.861
ENSSMAP00000016265	SMAX5B_007191	ENSSMAP00000016265	ENSSMAP00000011466	Chondroadherin.	Integrin beta; Belongs to the integrin beta chain family.	0.856
ENSSMAP00000016265	SMAX5B_010271	ENSSMAP00000016265	ENSSMAP00000019922	Chondroadherin.	Integrin beta; Belongs to the integrin beta chain family.	0.856
ENSSMAP00000016265	SMAX5B_010474	ENSSMAP00000016265	ENSSMAP00000012689	Chondroadherin.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.845
ENSSMAP00000016265	SMAX5B_012204	ENSSMAP00000016265	ENSSMAP00000026076	Chondroadherin.	Putative integrin alpha-10; Belongs to the integrin alpha chain family.	0.856
ENSSMAP00000016265	SMAX5B_013794	ENSSMAP00000016265	ENSSMAP00000012752	Chondroadherin.	Putative integrin alpha-1; Belongs to the integrin alpha chain family.	0.845
ENSSMAP00000016265	SMAX5B_015913	ENSSMAP00000016265	ENSSMAP00000018538	Chondroadherin.	Integrin beta; Belongs to the integrin beta chain family.	0.861
ENSSMAP00000016265	SMAX5B_020151	ENSSMAP00000016265	ENSSMAP00000006080	Chondroadherin.	Integrin beta.	0.861
ENSSMAP00000016265	SMAX5B_020277	ENSSMAP00000016265	ENSSMAP00000018492	Chondroadherin.	Putative integrin alpha-3; Belongs to the integrin alpha chain family.	0.844

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

9.22e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 298

1.49

3.05

1.60e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 167

1.75

4.58

1.39e-16

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

10 of 70

2.08

6.48

1.13e-17

GO:0005762

Mitochondrial large ribosomal subunit

8 of 41

2.22

6.13

8.87e-15

GO:0005840

Ribosome

11 of 183

1.71

4.42

6.79e-17

GO:0044391

Ribosomal subunit

10 of 154

1.74

4.31

4.98e-15

GO:0098798

Mitochondrial protein-containing complex

10 of 177

1.68

3.98

1.09e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4871

Organellar large ribosomal subunit, and Ribosomal protein L23

10 of 18

2.67

10.54

1.79e-22

CL:4863

Organellar ribosome

11 of 53

2.24

8.49

5.45e-22

CL:4893

Organellar large ribosomal subunit

5 of 6

2.85

5.39

7.63e-11

CL:4872

Mixed, incl. Ribosomal protein L23, and Organellar large ribosomal subunit

5 of 10

2.63

4.87

4.40e-10

CL:4874

Mixed, incl. Ribosomal protein L23, and Translation protein SH3-like domain superfamily

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

11 of 187

1.7

4.39

4.60e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

9 of 253

1.48

2.58

4.66e-10

MAP-392499

Metabolism of proteins

9 of 907

0.92

0.93

1.76e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005762

Mitochondrial large ribosomal subunit

9 of 38

2.3

7.35

1.68e-17

GOCC:0005761

Mitochondrial ribosome

10 of 64

2.12

6.74

5.70e-18

GOCC:0044391

Ribosomal subunit

10 of 141

1.78

4.55

1.97e-15

GOCC:0098798

Mitochondrial protein complex

10 of 168

1.7

4.12

5.94e-15

GOCC:0005739

Mitochondrion

11 of 684

1.13

1.66

3.63e-11

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 92

1.81

3.45

9.56e-10

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