ENSSMAP00000018605 protein (Scophthalmus maximus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSSMAP00000018605

annotation not available (124 aa)

Predicted Functional Partners:

SMAX5B_002416

0.952

SMAX5B_004759

0.952

SMAX5B_012905

0.952

SMAX5B_004121

0.952

SMAX5B_012257

0.949

SMAX5B_015320

0.930

SMAX5B_006373

0.930

SMAX5B_016833

0.913

SMAX5B_001062

0.913

SMAX5B_022376

0.903

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000018605	SMAX5B_001062	ENSSMAP00000018605	ENSSMAP00000020033	annotation not available	Putative AT-rich interactive domain-containing protein 4A isoform 2.	0.913
ENSSMAP00000018605	SMAX5B_002416	ENSSMAP00000018605	ENSSMAP00000009128	annotation not available	Putative lysine-specific demethylase 6A-like.	0.952
ENSSMAP00000018605	SMAX5B_004121	ENSSMAP00000018605	ENSSMAP00000031408	annotation not available	Putative lysine-specific demethylase 6B-like.	0.952
ENSSMAP00000018605	SMAX5B_004759	ENSSMAP00000018605	ENSSMAP00000017862	annotation not available	Putative lysine-specific demethylase 6A-like.	0.952
ENSSMAP00000018605	SMAX5B_006373	ENSSMAP00000018605	ENSSMAP00000031247	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.930
ENSSMAP00000018605	SMAX5B_012257	ENSSMAP00000018605	ENSSMAP00000018528	annotation not available	Putative histone H2B type 2-E-like; Belongs to the histone H2A family.	0.949
ENSSMAP00000018605	SMAX5B_012905	ENSSMAP00000018605	ENSSMAP00000026087	annotation not available	Putative lysine-specific demethylase 6B.	0.952
ENSSMAP00000018605	SMAX5B_015320	ENSSMAP00000018605	ENSSMAP00000016935	annotation not available	Histone H2B; Belongs to the histone H2A family.	0.930
ENSSMAP00000018605	SMAX5B_016833	ENSSMAP00000018605	ENSSMAP00000016989	annotation not available	Putative AT-rich interactive domain-containing protein 4B isoform 2.	0.913
ENSSMAP00000018605	SMAX5B_022376	ENSSMAP00000018605	ENSSMAP00000017546	annotation not available	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.903
SMAX5B_001062	ENSSMAP00000018605	ENSSMAP00000020033	ENSSMAP00000018605	Putative AT-rich interactive domain-containing protein 4A isoform 2.	annotation not available	0.913
SMAX5B_001062	SMAX5B_002416	ENSSMAP00000020033	ENSSMAP00000009128	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Putative lysine-specific demethylase 6A-like.	0.625
SMAX5B_001062	SMAX5B_004121	ENSSMAP00000020033	ENSSMAP00000031408	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Putative lysine-specific demethylase 6B-like.	0.595
SMAX5B_001062	SMAX5B_004759	ENSSMAP00000020033	ENSSMAP00000017862	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Putative lysine-specific demethylase 6A-like.	0.625
SMAX5B_001062	SMAX5B_006373	ENSSMAP00000020033	ENSSMAP00000031247	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Histone H2B; Belongs to the histone H2B family.	0.794
SMAX5B_001062	SMAX5B_012257	ENSSMAP00000020033	ENSSMAP00000018528	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Putative histone H2B type 2-E-like; Belongs to the histone H2A family.	0.794
SMAX5B_001062	SMAX5B_012905	ENSSMAP00000020033	ENSSMAP00000026087	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Putative lysine-specific demethylase 6B.	0.595
SMAX5B_001062	SMAX5B_015320	ENSSMAP00000020033	ENSSMAP00000016935	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Histone H2B; Belongs to the histone H2A family.	0.794
SMAX5B_001062	SMAX5B_016833	ENSSMAP00000020033	ENSSMAP00000016989	Putative AT-rich interactive domain-containing protein 4A isoform 2.	Putative AT-rich interactive domain-containing protein 4B isoform 2.	0.752
SMAX5B_002416	ENSSMAP00000018605	ENSSMAP00000009128	ENSSMAP00000018605	Putative lysine-specific demethylase 6A-like.	annotation not available	0.952

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.89

expected number of edges:

18

PPI enrichment p-value:

9.7e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 296

1.51

2.89

9.61e-12

GO:0000028

Ribosomal small subunit assembly

2 of 7

2.43

1.32

0.0037

GO:0009987

Cellular process

11 of 5102

0.31

0.25

0.0328

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 153

1.75

3.85

2.64e-12

GO:0019843

rRNA binding

4 of 57

1.82

1.87

0.00010

GO:0003723

RNA binding

7 of 497

1.13

1.15

6.47e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

9 of 167

1.71

3.71

2.68e-12

GO:0044391

Ribosomal subunit

7 of 94

1.85

3.61

5.78e-10

GO:0015935

Small ribosomal subunit

5 of 37

2.11

3.38

6.83e-08

GO:0022626

Cytosolic ribosome

3 of 56

1.71

1.31

0.0017

GO:0022627

Cytosolic small ribosomal subunit

2 of 18

2.02

1.09

0.0083

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23734264

(2013) Complete sequence and analysis of plastid genomes of two economically important red algae: Pyropia haitanensis and Pyropia yezoensis.

3 of 38

1.88

1.09

0.0072

PMID:20502706

(2010) The complete plastid genomes of the two dinotoms Durinskia baltica and Kryptoperidinium foliaceum.

3 of 43

1.82

1.08

0.0072

PMID:20333213

(2009) The complete plastid genome sequence of the secondarily nonphotosynthetic alga Cryptomonas paramecium: reduction, compaction, and accelerated evolutionary rate.

3 of 53

1.73

1.06

0.0072

PMID:26780836

(2016) Algorithms for reconstruction of chromosomal structures.

3 of 63

1.66

1.03

0.0076

PMID:34966403

(2021) Chloroplast Genomes for Five Skeletonema Species: Comparative and Phylogenetic Analysis.

3 of 92

1.49

0.82

0.0180

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:543

Ribosome, and RRF superfamily

5 of 57

1.92

2.79

5.94e-07

CL:276

GTP hydrolysis and joining of the 60S ribosomal subunit, and rRNA-binding

6 of 101

1.75

2.55

5.94e-07

CL:283

Ribosome

4 of 74

1.71

1.75

0.00012

CL:568

Mixed, incl. L28p-like, and Ribosomal protein L9

2 of 6

2.5

1.42

0.0024

CL:555

Ribosome

3 of 42

1.83

1.41

0.0013

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pti03010

Ribosome

5 of 91

1.72

2.3

2.77e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

7 of 241

1.44

1.96

9.37e-07

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

3 of 85

1.53

0.81

0.0209

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

3 of 81

1.55

0.81

0.0209

MAP-975957

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

3 of 91

1.5

0.8

0.0209

MAP-927802

Nonsense-Mediated Decay (NMD)

3 of 91

1.5

0.8

0.0209

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009536

Plastid

5 of 195

1.39

1.24

0.00069

GOCC:0005840

Ribosome

3 of 64

1.65

1.08

0.0054

GOCC:0009507

Chloroplast

4 of 149

1.41

1.06

0.0030

GOCC:0005737

Cytoplasm

10 of 2342

0.61

0.49

0.00097

GOCC:0043229

Intracellular organelle

10 of 3005

0.5

0.38

0.0054

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 91

1.72

2.2

5.80e-06

KW-0699

rRNA-binding

2 of 32

1.77

0.75

0.0353

KW-0694

RNA-binding

3 of 151

1.28

0.65

0.0353

KW-0150

Chloroplast

3 of 174

1.21

0.63

0.0353

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00177

Ribosomal protein S7p/S5e

2 of 2

2.98

1.22

0.0063

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036823

Ribosomal protein S7 domain superfamily

2 of 2

2.98

0.97

0.0180

IPR023798

Ribosomal protein S7 domain

2 of 2

2.98

0.97

0.0180

IPR020606

Ribosomal protein S7, conserved site

2 of 2

2.98

0.97

0.0180

IPR000235

Ribosomal protein S5/S7

2 of 2

2.98

0.97

0.0180

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