SMAX5B_003996 protein (Scophthalmus maximus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

SMAX5B_003996

Serine/threonine-protein phosphatase. (522 aa)

Predicted Functional Partners:

SMAX5B_008579

0.958

ENSSMAP00000031425

0.943

SMAX5B_008745

0.943

SMAX5B_009561

0.936

SMAX5B_015767

0.936

SMAX5B_008647

0.911

ENSSMAP00000025079

0.911

CALML6

0.909

SMAX5B_014850

0.896

SMAX5B_005203

0.895

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML6	ENSSMAP00000025079	ENSSMAP00000026691	ENSSMAP00000025079	Calmodulin like 6.	annotation not available	0.843
CALML6	ENSSMAP00000031425	ENSSMAP00000026691	ENSSMAP00000031425	Calmodulin like 6.	annotation not available	0.904
CALML6	SMAX5B_003996	ENSSMAP00000026691	ENSSMAP00000019009	Calmodulin like 6.	Serine/threonine-protein phosphatase.	0.909
CALML6	SMAX5B_008579	ENSSMAP00000026691	ENSSMAP00000031387	Calmodulin like 6.	Putative WD repeat-containing protein 92 isoform 2.	0.661
CALML6	SMAX5B_008647	ENSSMAP00000026691	ENSSMAP00000023006	Calmodulin like 6.	Calmodulin; Belongs to the calmodulin family.	0.843
CALML6	SMAX5B_008745	ENSSMAP00000026691	ENSSMAP00000034405	Calmodulin like 6.	Putative calcineurin subunit B type 1.	0.904
CALML6	SMAX5B_009561	ENSSMAP00000026691	ENSSMAP00000012526	Calmodulin like 6.	Putative nuclear factor of activated T-cells cytoplasmic 1-like.	0.551
CALML6	SMAX5B_014850	ENSSMAP00000026691	ENSSMAP00000031218	Calmodulin like 6.	Putative nuclear factor of activated T-cells cytoplasmic 2.	0.618
CALML6	SMAX5B_015767	ENSSMAP00000026691	ENSSMAP00000032079	Calmodulin like 6.	Putative nuclear factor of activated T-cells cytoplasmic 1-like.	0.551
ENSSMAP00000025079	CALML6	ENSSMAP00000025079	ENSSMAP00000026691	annotation not available	Calmodulin like 6.	0.843
ENSSMAP00000025079	ENSSMAP00000031425	ENSSMAP00000025079	ENSSMAP00000031425	annotation not available	annotation not available	0.865
ENSSMAP00000025079	SMAX5B_003996	ENSSMAP00000025079	ENSSMAP00000019009	annotation not available	Serine/threonine-protein phosphatase.	0.911
ENSSMAP00000025079	SMAX5B_008579	ENSSMAP00000025079	ENSSMAP00000031387	annotation not available	Putative WD repeat-containing protein 92 isoform 2.	0.635
ENSSMAP00000025079	SMAX5B_008745	ENSSMAP00000025079	ENSSMAP00000034405	annotation not available	Putative calcineurin subunit B type 1.	0.865
ENSSMAP00000025079	SMAX5B_009561	ENSSMAP00000025079	ENSSMAP00000012526	annotation not available	Putative nuclear factor of activated T-cells cytoplasmic 1-like.	0.498
ENSSMAP00000025079	SMAX5B_014850	ENSSMAP00000025079	ENSSMAP00000031218	annotation not available	Putative nuclear factor of activated T-cells cytoplasmic 2.	0.579
ENSSMAP00000025079	SMAX5B_015767	ENSSMAP00000025079	ENSSMAP00000032079	annotation not available	Putative nuclear factor of activated T-cells cytoplasmic 1-like.	0.498
ENSSMAP00000031425	CALML6	ENSSMAP00000031425	ENSSMAP00000026691	annotation not available	Calmodulin like 6.	0.904
ENSSMAP00000031425	ENSSMAP00000025079	ENSSMAP00000031425	ENSSMAP00000025079	annotation not available	annotation not available	0.865
ENSSMAP00000031425	SMAX5B_003996	ENSSMAP00000031425	ENSSMAP00000019009	annotation not available	Serine/threonine-protein phosphatase.	0.943

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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