ENSSMAP00000019181 protein (Scophthalmus maximus)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ENSSMAP00000019181

annotation not available (736 aa)

Predicted Functional Partners:

SMAX5B_006177

0.698

SMAX5B_005892

0.698

SMAX5B_020477

0.643

SMAX5B_002120

0.633

SMAX5B_010168

0.581

SMAX5B_018385

0.550

SMAX5B_007980

0.531

SMAX5B_009105

0.497

SMAX5B_018222

0.497

SMAX5B_003015

0.497

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000019181	SMAX5B_002120	ENSSMAP00000019181	ENSSMAP00000000080	annotation not available	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.633
ENSSMAP00000019181	SMAX5B_003015	ENSSMAP00000019181	ENSSMAP00000018723	annotation not available	Putative N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.497
ENSSMAP00000019181	SMAX5B_005892	ENSSMAP00000019181	ENSSMAP00000014680	annotation not available	Putative complement factor H-like.	0.698
ENSSMAP00000019181	SMAX5B_006177	ENSSMAP00000019181	ENSSMAP00000014617	annotation not available	Putative complement factor H-like isoform 3.	0.698
ENSSMAP00000019181	SMAX5B_007980	ENSSMAP00000019181	ENSSMAP00000007706	annotation not available	Putative zinc finger protein 408-like.	0.531
ENSSMAP00000019181	SMAX5B_009105	ENSSMAP00000019181	ENSSMAP00000010475	annotation not available	Putative acetylserotonin O-methyltransferase.	0.497
ENSSMAP00000019181	SMAX5B_010168	ENSSMAP00000019181	ENSSMAP00000033670	annotation not available	Protease nexin 1; Belongs to the serpin family.	0.581
ENSSMAP00000019181	SMAX5B_018222	ENSSMAP00000019181	ENSSMAP00000013352	annotation not available	Methyl transferase.	0.497
ENSSMAP00000019181	SMAX5B_018385	ENSSMAP00000019181	ENSSMAP00000006406	annotation not available	Putative N-acetylserotonin O-methyltransferase-like protein-like; Belongs to the G-protein coupled receptor 1 family.	0.550
ENSSMAP00000019181	SMAX5B_020477	ENSSMAP00000019181	ENSSMAP00000030689	annotation not available	Putative complement factor H-like isoform 3.	0.643
SMAX5B_002120	ENSSMAP00000019181	ENSSMAP00000000080	ENSSMAP00000019181	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	annotation not available	0.633
SMAX5B_002120	SMAX5B_005892	ENSSMAP00000000080	ENSSMAP00000014680	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Putative complement factor H-like.	0.547
SMAX5B_002120	SMAX5B_006177	ENSSMAP00000000080	ENSSMAP00000014617	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Putative complement factor H-like isoform 3.	0.547
SMAX5B_002120	SMAX5B_010168	ENSSMAP00000000080	ENSSMAP00000033670	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protease nexin 1; Belongs to the serpin family.	0.977
SMAX5B_002120	SMAX5B_020477	ENSSMAP00000000080	ENSSMAP00000030689	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Putative complement factor H-like isoform 3.	0.606
SMAX5B_003015	ENSSMAP00000019181	ENSSMAP00000018723	ENSSMAP00000019181	Putative N-terminal Xaa-Pro-Lys N-methyltransferase 1.	annotation not available	0.497
SMAX5B_003015	SMAX5B_018385	ENSSMAP00000018723	ENSSMAP00000006406	Putative N-terminal Xaa-Pro-Lys N-methyltransferase 1.	Putative N-acetylserotonin O-methyltransferase-like protein-like; Belongs to the G-protein coupled receptor 1 family.	0.669
SMAX5B_005892	ENSSMAP00000019181	ENSSMAP00000014680	ENSSMAP00000019181	Putative complement factor H-like.	annotation not available	0.698
SMAX5B_005892	SMAX5B_002120	ENSSMAP00000014680	ENSSMAP00000000080	Putative complement factor H-like.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.547
SMAX5B_006177	ENSSMAP00000019181	ENSSMAP00000014617	ENSSMAP00000019181	Putative complement factor H-like isoform 3.	annotation not available	0.698

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

17

PPI enrichment p-value:

3.4e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098609

Cell-cell adhesion

5 of 435

1.54

1.27

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045294

Alpha-catenin binding

2 of 10

2.78

0.97

0.0174

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0014704

Intercalated disc

2 of 11

2.74

1.28

0.0048

GO:0005911

Cell-cell junction

4 of 317

1.58

1.15

0.0032

GO:0016342

Catenin complex

2 of 30

2.31

0.98

0.0154

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37965

Cadherin-like superfamily, and Plakophilin/Delta catenin

5 of 97

2.2

3.1

5.32e-07

CL:38071

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 11

2.92

2.95

3.94e-06

CL:6049

RHOU GTPase cycle, and Unconventional class IX myosin

3 of 14

2.81

2.83

6.30e-06

CL:37972

Cadherin-like superfamily, and Plakophilin/Delta catenin

4 of 85

2.16

2.61

5.75e-06

CL:38074

Limb expression 1, and Retina layer formation

2 of 5

3.09

1.87

0.00042

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

3 of 102

1.95

1.51

0.00098

map04520

Adherens junction

3 of 115

1.9

1.49

0.00098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013026

RHOB GTPase cycle

3 of 71

2.11

1.35

0.0027

MAP-8980692

RHOA GTPase cycle

3 of 178

1.71

0.86

0.0199

MAP-5218920

VEGFR2 mediated vascular permeability

2 of 35

2.24

0.79

0.0347

MAP-418990

Adherens junctions interactions

2 of 40

2.18

0.79

0.0347

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005911

Cell-cell junction

4 of 224

1.74

1.42

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 56

2.04

0.7

0.0499

KW-0106

Calcium

3 of 368

1.39

0.62

0.0499

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046987

Unconventional class IX myosin

3 of 4

3.36

2.87

6.62e-06

IPR036023

Class IX myosin, motor domain

2 of 2

3.48

1.49

0.0021

IPR013284

Beta-catenin

2 of 3

3.31

1.47

0.0023

IPR020894

Cadherin conserved site

3 of 107

1.93

1.04

0.0100

IPR015919

Cadherin-like superfamily

3 of 122

1.87

0.99

0.0118

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00112

Cadherin repeats.

3 of 118

1.89

1.14

0.0057

SM00314

Ras association (RalGDS/AF-6) domain

2 of 30

2.31

0.94

0.0187

SM00185

Armadillo/beta-catenin-like repeats

2 of 32

2.28

0.94

0.0187

SM00242

Myosin. Large ATPases.

2 of 38

2.2

0.93

0.0187

SM00282

Laminin G domain

2 of 50

2.09

0.91

0.0199

(more ...)

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