STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dis3l2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1049 aa)    
Predicted Functional Partners:
SMAX5B_014891
Putative exosome component 10 isoform 2.
  
 0.985
SMAX5B_013955
Superkiller viralicidic activity 2-like 2.
   
 0.974
ENSSMAP00000006047
Exosome component 1.
   
 0.973
SMAX5B_019774
Putative exosome complex component RRP45.
   
 0.973
SMAX5B_005803
Exosome complex exonuclease RRP41.
  
 0.973
SMAX5B_015877
Exosome complex exonuclease RRP42.
   
 0.973
SMAX5B_012393
Putative exosome complex component RRP43.
   
 0.972
SMAX5B_019872
Putative exosome complex component RRP46.
  
 0.972
ENSSMAP00000005079
Exosome component 2.
   
 0.970
SMAX5B_003963
Putative exosome complex component MTR3.
  
 0.970
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.