SMAX5B_006561 protein (Scophthalmus maximus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

SMAX5B_006561

Uncharacterized protein. (230 aa)

Predicted Functional Partners:

SMAX5B_016005

0.737

SMAX5B_018231

0.672

ENSSMAP00000011591

0.566

NEK9

0.475

SMAX5B_004815

0.470

SMAX5B_019977

0.470

SMAX5B_004773

0.470

SMAX5B_017577

0.470

SMAX5B_021918

0.456

SMAX5B_019216

0.428

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000011591	NEK9	ENSSMAP00000011591	ENSSMAP00000007486	annotation not available	Putative serine/threonine-protein kinase Nek9.	0.434
ENSSMAP00000011591	SMAX5B_006561	ENSSMAP00000011591	ENSSMAP00000021042	annotation not available	Uncharacterized protein.	0.566
ENSSMAP00000011591	SMAX5B_018231	ENSSMAP00000011591	ENSSMAP00000011619	annotation not available	Putative alsin-like.	0.919
NEK9	ENSSMAP00000011591	ENSSMAP00000007486	ENSSMAP00000011591	Putative serine/threonine-protein kinase Nek9.	annotation not available	0.434
NEK9	SMAX5B_006561	ENSSMAP00000007486	ENSSMAP00000021042	Putative serine/threonine-protein kinase Nek9.	Uncharacterized protein.	0.475
NEK9	SMAX5B_016005	ENSSMAP00000007486	ENSSMAP00000002200	Putative serine/threonine-protein kinase Nek9.	Putative alsin.	0.434
NEK9	SMAX5B_018231	ENSSMAP00000007486	ENSSMAP00000011619	Putative serine/threonine-protein kinase Nek9.	Putative alsin-like.	0.434
NEK9	SMAX5B_021918	ENSSMAP00000007486	ENSSMAP00000030875	Putative serine/threonine-protein kinase Nek9.	Putative spermatogenesis-associated protein 7.	0.419
SMAX5B_004773	SMAX5B_006561	ENSSMAP00000016943	ENSSMAP00000021042	Putative serine/threonine-protein kinase Nek5-like.	Uncharacterized protein.	0.470
SMAX5B_004773	SMAX5B_016005	ENSSMAP00000016943	ENSSMAP00000002200	Putative serine/threonine-protein kinase Nek5-like.	Putative alsin.	0.497
SMAX5B_004773	SMAX5B_018231	ENSSMAP00000016943	ENSSMAP00000011619	Putative serine/threonine-protein kinase Nek5-like.	Putative alsin-like.	0.420
SMAX5B_004815	SMAX5B_006561	ENSSMAP00000002707	ENSSMAP00000021042	Putative cytoskeleton-associated protein 2-like isoform 3.	Uncharacterized protein.	0.470
SMAX5B_004815	SMAX5B_016005	ENSSMAP00000002707	ENSSMAP00000002200	Putative cytoskeleton-associated protein 2-like isoform 3.	Putative alsin.	0.483
SMAX5B_004815	SMAX5B_018231	ENSSMAP00000002707	ENSSMAP00000011619	Putative cytoskeleton-associated protein 2-like isoform 3.	Putative alsin-like.	0.420
SMAX5B_006561	ENSSMAP00000011591	ENSSMAP00000021042	ENSSMAP00000011591	Uncharacterized protein.	annotation not available	0.566
SMAX5B_006561	NEK9	ENSSMAP00000021042	ENSSMAP00000007486	Uncharacterized protein.	Putative serine/threonine-protein kinase Nek9.	0.475
SMAX5B_006561	SMAX5B_004773	ENSSMAP00000021042	ENSSMAP00000016943	Uncharacterized protein.	Putative serine/threonine-protein kinase Nek5-like.	0.470
SMAX5B_006561	SMAX5B_004815	ENSSMAP00000021042	ENSSMAP00000002707	Uncharacterized protein.	Putative cytoskeleton-associated protein 2-like isoform 3.	0.470
SMAX5B_006561	SMAX5B_016005	ENSSMAP00000021042	ENSSMAP00000002200	Uncharacterized protein.	Putative alsin.	0.737
SMAX5B_006561	SMAX5B_017577	ENSSMAP00000021042	ENSSMAP00000021127	Uncharacterized protein.	Putative serine/threonine-protein kinase Nek1.	0.470

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.863

expected number of edges:

11

PPI enrichment p-value:

3.88e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

7 of 29

2.66

6.96

2.06e-14

GO:0046040

IMP metabolic process

6 of 25

2.66

6.05

1.76e-12

GO:0046128

Purine ribonucleoside metabolic process

6 of 26

2.64

6.01

2.01e-12

GO:0006167

AMP biosynthetic process

5 of 13

2.87

5.51

4.67e-11

GO:0072522

Purine-containing compound biosynthetic process

9 of 174

1.99

5.23

2.59e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004019

Adenylosuccinate synthase activity

3 of 3

3.28

3.07

2.84e-06

GO:0000287

Magnesium ion binding

6 of 195

1.77

2.53

8.42e-07

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 50

2.18

2.5

1.13e-05

GO:0016763

Pentosyltransferase activity

4 of 58

2.12

2.4

1.49e-05

GO:0047975

Guanosine phosphorylase activity

2 of 5

2.88

1.53

0.0017

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25463

Purine ribonucleoside monophosphate metabolic process, and Adenosine metabolic process

10 of 39

2.69

10.86

4.28e-23

CL:25459

Mixed, incl. Purine nucleoside monophosphate metabolic process, and 5-nucleotidase activity

11 of 76

2.44

10.04

1.39e-23

CL:25466

Purine ribonucleoside monophosphate biosynthesis, and GMP reductase

7 of 23

2.76

7.69

1.17e-15

CL:25467

Mixed, incl. IMP dehydrogenase/GMP reductase, and 5-nucleotidase

4 of 15

2.71

3.77

8.57e-08

CL:25515

Ribonucleoside biosynthetic process

3 of 12

2.68

2.5

2.35e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

11 of 292

1.86

5.52

9.14e-19

map00760

Nicotinate and nicotinamide metabolism

4 of 74

2.01

2.59

3.70e-06

map00240

Pyrimidine metabolism

4 of 128

1.78

2.06

2.32e-05

map00250

Alanine, aspartate and glutamate metabolism

3 of 69

1.92

1.77

0.00024

map01100

Metabolic pathways

11 of 3033

0.84

0.91

5.67e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-15869

Metabolism of nucleotides

11 of 138

2.18

7.96

2.61e-21

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

5 of 19

2.7

4.9

4.77e-10

MAP-8956320

Nucleotide biosynthesis

5 of 22

2.64

4.81

6.03e-10

MAP-74259

Purine catabolism

4 of 23

2.52

3.47

2.36e-07

MAP-74217

Purine salvage

4 of 29

2.42

3.28

4.58e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

4 of 9

2.93

4.35

9.28e-09

KW-0436

Ligase

3 of 112

1.71

1.16

0.0041

KW-0460

Magnesium

3 of 149

1.58

1.03

0.0063

KW-0342

GTP-binding

3 of 205

1.45

0.88

0.0119

KW-0963

Cytoplasm

3 of 292

1.29

0.7

0.0266

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06189

5-nucleotidase

2 of 4

2.98

1.15

0.0085

PF01048

Phosphorylase superfamily

2 of 7

2.74

1.1

0.0102

PF00156

Phosphoribosyl transferase domain

2 of 8

2.68

1.1

0.0102

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042111

Adenylosuccinate synthetase, domain 3

3 of 3

3.28

2.68

1.45e-05

IPR042110

Adenylosuccinate synthetase, domain 2

3 of 3

3.28

2.68

1.45e-05

IPR042109

Adenylosuccinate synthetase, domain 1

3 of 3

3.28

2.68

1.45e-05

IPR033128

Adenylosuccinate synthase, active site

3 of 3

3.28

2.68

1.45e-05

IPR018220

Adenylosuccinate synthase, GTP-binding site

3 of 3

3.28

2.68

1.45e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00788

Adenylosuccinate synthetase

3 of 3

3.28

3.19

1.66e-06

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