SMAX5B_000765 protein (Scophthalmus maximus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SMAX5B_000765

Putative tetratricopeptide repeat protein 16-like. (398 aa)

Predicted Functional Partners:

SMAX5B_012522

0.930

SMAX5B_019619

0.864

SMAX5B_010919

0.804

SMAX5B_018506

0.803

SMAX5B_017663

0.803

SMAX5B_005270

0.801

ENSSMAP00000017200

0.798

SMAX5B_020684

0.792

SMAX5B_000774

0.792

SMAX5B_000262

0.777

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000017200	SMAX5B_000262	ENSSMAP00000017200	ENSSMAP00000007253	annotation not available	TPR_REGION domain-containing protein.	0.798
ENSSMAP00000017200	SMAX5B_000765	ENSSMAP00000017200	ENSSMAP00000021525	annotation not available	Putative tetratricopeptide repeat protein 16-like.	0.798
ENSSMAP00000017200	SMAX5B_000774	ENSSMAP00000017200	ENSSMAP00000021349	annotation not available	Putative peroxisomal NADH pyrophosphatase NUDT12.	0.529
ENSSMAP00000017200	SMAX5B_010919	ENSSMAP00000017200	ENSSMAP00000002671	annotation not available	Putative anaphase-promoting complex subunit 5.	0.730
ENSSMAP00000017200	SMAX5B_012522	ENSSMAP00000017200	ENSSMAP00000023325	annotation not available	Putative RNA polymerase-associated protein LEO1-like.	0.998
ENSSMAP00000017200	SMAX5B_017663	ENSSMAP00000017200	ENSSMAP00000021541	annotation not available	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.810
ENSSMAP00000017200	SMAX5B_018506	ENSSMAP00000017200	ENSSMAP00000006216	annotation not available	TPR_REGION domain-containing protein.	0.813
ENSSMAP00000017200	SMAX5B_019619	ENSSMAP00000017200	ENSSMAP00000023479	annotation not available	Putative adenylate kinase 9 isoform 2.	0.506
ENSSMAP00000017200	SMAX5B_020684	ENSSMAP00000017200	ENSSMAP00000019227	annotation not available	Putative anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.743
SMAX5B_000262	ENSSMAP00000017200	ENSSMAP00000007253	ENSSMAP00000017200	TPR_REGION domain-containing protein.	annotation not available	0.798
SMAX5B_000262	SMAX5B_000765	ENSSMAP00000007253	ENSSMAP00000021525	TPR_REGION domain-containing protein.	Putative tetratricopeptide repeat protein 16-like.	0.777
SMAX5B_000262	SMAX5B_000774	ENSSMAP00000007253	ENSSMAP00000021349	TPR_REGION domain-containing protein.	Putative peroxisomal NADH pyrophosphatase NUDT12.	0.653
SMAX5B_000262	SMAX5B_005270	ENSSMAP00000007253	ENSSMAP00000027166	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.996
SMAX5B_000262	SMAX5B_010919	ENSSMAP00000007253	ENSSMAP00000002671	TPR_REGION domain-containing protein.	Putative anaphase-promoting complex subunit 5.	0.802
SMAX5B_000262	SMAX5B_012522	ENSSMAP00000007253	ENSSMAP00000023325	TPR_REGION domain-containing protein.	Putative RNA polymerase-associated protein LEO1-like.	0.930
SMAX5B_000262	SMAX5B_017663	ENSSMAP00000007253	ENSSMAP00000021541	TPR_REGION domain-containing protein.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.803
SMAX5B_000262	SMAX5B_018506	ENSSMAP00000007253	ENSSMAP00000006216	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.803
SMAX5B_000262	SMAX5B_019619	ENSSMAP00000007253	ENSSMAP00000023479	TPR_REGION domain-containing protein.	Putative adenylate kinase 9 isoform 2.	0.827
SMAX5B_000262	SMAX5B_020684	ENSSMAP00000007253	ENSSMAP00000019227	TPR_REGION domain-containing protein.	Putative anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.792
SMAX5B_000765	ENSSMAP00000017200	ENSSMAP00000021525	ENSSMAP00000017200	Putative tetratricopeptide repeat protein 16-like.	annotation not available	0.798

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.968

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045039

Protein insertion into mitochondrial inner membrane

3 of 7

3.0

2.53

2.54e-05

GO:0046834

Lipid phosphorylation

2 of 2

3.37

1.79

0.00060

GO:0046512

Sphingosine biosynthetic process

2 of 5

2.97

1.59

0.0013

GO:0006121

Mitochondrial electron transport, succinate to ubiquinone

2 of 6

2.89

1.59

0.0013

GO:0006099

Tricarboxylic acid cycle

2 of 29

2.2

1.05

0.0111

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140318

Protein transporter activity

3 of 25

2.44

1.87

0.00032

GO:0004402

Histone acetyltransferase activity

2 of 23

2.3

0.85

0.0274

GO:0140110

Transcription regulator activity

4 of 412

1.35

0.78

0.0171

GO:0046872

Metal ion binding

6 of 2233

0.79

0.46

0.0331

GO:0005488

Binding

10 of 7866

0.47

0.32

0.0274

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042721

TIM22 mitochondrial import inner membrane insertion complex

3 of 4

3.24

3.32

9.53e-07

GO:0098800

Inner mitochondrial membrane protein complex

5 of 120

1.99

2.79

9.53e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 3

3.19

2.13

0.00014

GO:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

2 of 5

2.97

1.98

0.00026

GO:0032991

Protein-containing complex

6 of 2897

0.68

0.45

0.0164

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24142

Tim10-like, and TIM22 mitochondrial import inner membrane insertion complex

3 of 7

3.0

2.59

1.96e-05

CL:19911

Fumarate reductase complex

2 of 5

2.97

1.48

0.0021

CL:1544

Mixed, incl. Lectin, and Met-10+ like-protein

2 of 11

2.63

1.31

0.0040

CL:21436

Sphingolipid metabolism

2 of 18

2.41

1.12

0.0088

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

2 of 49

1.98

0.79

0.0330

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 72

1.99

1.25

0.0037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 4

3.06

1.6

0.0013

GOCC:0045281

Succinate dehydrogenase complex

2 of 7

2.82

1.52

0.0017

GOCC:0098798

Mitochondrial protein complex

4 of 184

1.7

1.42

0.00090

GOCC:0005740

Mitochondrial envelope

4 of 367

1.4

1.12

0.0019

GOCC:0098800

Inner mitochondrial membrane protein complex

2 of 75

1.79

0.82

0.0255

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 13

2.55

1.41

0.0026

KW-0496

Mitochondrion

3 of 102

1.83

1.28

0.0026

KW-1015

Disulfide bond

2 of 92

1.7

0.7

0.0428

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

2 of 4

3.06

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034804

Fumarate reductase/succinate dehydrogenase, transmembrane subunit

2 of 3

3.19

1.39

0.0032

IPR001206

Diacylglycerol kinase, catalytic domain

2 of 2

3.37

1.39

0.0032

IPR035427

Tim10-like domain superfamily

2 of 4

3.06

1.38

0.0032

IPR017438

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

2 of 5

2.97

1.38

0.0032

IPR016064

NAD kinase/diacylglycerol kinase-like domain superfamily

2 of 5

2.97

1.38

0.0032

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About