SMAX5B_005469 protein (Scophthalmus maximus)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SMAX5B_005469

Putative DENN domain-containing protein 5B-like. (1373 aa)

Predicted Functional Partners:

ENSSMAP00000000530

0.619

SMAX5B_007955

0.619

SMAX5B_009372

0.619

SMAX5B_004090

0.619

SMAX5B_021501

0.618

RAB28

0.517

SMAX5B_019865

0.444

SMAX5B_022177

0.444

SMAX5B_016220

0.444

DENND3

0.417

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DENND3	RAB28	ENSSMAP00000009126	ENSSMAP00000018426	Putative DENN domain-containing protein 3-like.	Putative ras-related protein Rab-28.	0.625
DENND3	SMAX5B_005469	ENSSMAP00000009126	ENSSMAP00000026306	Putative DENN domain-containing protein 3-like.	Putative DENN domain-containing protein 5B-like.	0.417
ENSSMAP00000000530	SMAX5B_005469	ENSSMAP00000000530	ENSSMAP00000026306	RAB6B, member RAS oncogene family b.	Putative DENN domain-containing protein 5B-like.	0.619
ENSSMAP00000000530	SMAX5B_021501	ENSSMAP00000000530	ENSSMAP00000026074	RAB6B, member RAS oncogene family b.	Putative rab proteins geranylgeranyltransferase component A 1-like.	0.712
RAB28	DENND3	ENSSMAP00000018426	ENSSMAP00000009126	Putative ras-related protein Rab-28.	Putative DENN domain-containing protein 3-like.	0.625
RAB28	SMAX5B_005469	ENSSMAP00000018426	ENSSMAP00000026306	Putative ras-related protein Rab-28.	Putative DENN domain-containing protein 5B-like.	0.517
RAB28	SMAX5B_021501	ENSSMAP00000018426	ENSSMAP00000026074	Putative ras-related protein Rab-28.	Putative rab proteins geranylgeranyltransferase component A 1-like.	0.711
SMAX5B_004090	SMAX5B_005469	ENSSMAP00000028146	ENSSMAP00000026306	Ras-related protein Rab-6A.	Putative DENN domain-containing protein 5B-like.	0.619
SMAX5B_004090	SMAX5B_021501	ENSSMAP00000028146	ENSSMAP00000026074	Ras-related protein Rab-6A.	Putative rab proteins geranylgeranyltransferase component A 1-like.	0.712
SMAX5B_005469	DENND3	ENSSMAP00000026306	ENSSMAP00000009126	Putative DENN domain-containing protein 5B-like.	Putative DENN domain-containing protein 3-like.	0.417
SMAX5B_005469	ENSSMAP00000000530	ENSSMAP00000026306	ENSSMAP00000000530	Putative DENN domain-containing protein 5B-like.	RAB6B, member RAS oncogene family b.	0.619
SMAX5B_005469	RAB28	ENSSMAP00000026306	ENSSMAP00000018426	Putative DENN domain-containing protein 5B-like.	Putative ras-related protein Rab-28.	0.517
SMAX5B_005469	SMAX5B_004090	ENSSMAP00000026306	ENSSMAP00000028146	Putative DENN domain-containing protein 5B-like.	Ras-related protein Rab-6A.	0.619
SMAX5B_005469	SMAX5B_007955	ENSSMAP00000026306	ENSSMAP00000002559	Putative DENN domain-containing protein 5B-like.	Uncharacterized protein.	0.619
SMAX5B_005469	SMAX5B_009372	ENSSMAP00000026306	ENSSMAP00000025801	Putative DENN domain-containing protein 5B-like.	MGC113973 wu:fi30c11.	0.619
SMAX5B_005469	SMAX5B_016220	ENSSMAP00000026306	ENSSMAP00000032732	Putative DENN domain-containing protein 5B-like.	Putative ras-related protein Rab-36-like.	0.444
SMAX5B_005469	SMAX5B_019865	ENSSMAP00000026306	ENSSMAP00000007047	Putative DENN domain-containing protein 5B-like.	Putative ras-related protein Rab-34.	0.444
SMAX5B_005469	SMAX5B_021501	ENSSMAP00000026306	ENSSMAP00000026074	Putative DENN domain-containing protein 5B-like.	Putative rab proteins geranylgeranyltransferase component A 1-like.	0.618
SMAX5B_005469	SMAX5B_022177	ENSSMAP00000026306	ENSSMAP00000032525	Putative DENN domain-containing protein 5B-like.	Putative ras-related protein Rab-34-like isoform 3.	0.444
SMAX5B_007955	SMAX5B_005469	ENSSMAP00000002559	ENSSMAP00000026306	Uncharacterized protein.	Putative DENN domain-containing protein 5B-like.	0.619

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

4.11e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015813

L-glutamate transmembrane transport

8 of 34

2.68

8.21

4.55e-17

GO:0015804

Neutral amino acid transport

8 of 64

2.41

7.02

1.02e-15

GO:0098657

Import into cell

10 of 158

2.11

6.5

3.39e-17

GO:0140009

L-aspartate import across plasma membrane

5 of 8

3.11

6.13

5.03e-12

GO:0098712

L-glutamate import across plasma membrane

5 of 12

2.93

5.77

1.70e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015501

Glutamate:sodium symporter activity

7 of 14

3.01

8.7

3.97e-17

GO:0015370

Solute:sodium symporter activity

10 of 102

2.3

8.03

1.67e-19

GO:0005313

L-glutamate transmembrane transporter activity

7 of 25

2.76

7.79

6.81e-16

GO:0015175

Neutral amino acid transmembrane transporter activity

7 of 62

2.37

6.14

9.50e-14

GO:0008509

Anion transmembrane transporter activity

10 of 358

1.76

4.43

2.94e-15

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045202

Synapse

10 of 1052

1.29

2.02

6.44e-10

GO:0098793

Presynapse

5 of 385

1.43

1.51

8.55e-05

GO:0005887

Integral component of plasma membrane

9 of 1342

1.14

1.44

1.90e-07

GO:0032809

Neuronal cell body membrane

2 of 23

2.25

1.19

0.0060

GO:0045121

Membrane raft

3 of 138

1.65

1.13

0.0042

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:39553

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

10 of 20

3.01

12.83

1.55e-25

CL:39555

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

8 of 15

3.04

10.29

3.08e-20

CL:39557

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

7 of 10

3.16

9.3

4.84e-18

CL:39559

D-amino acid transport, and Dopamine:sodium symporter activity

3 of 5

3.09

3.14

1.97e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 47

2.49

6.68

1.89e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-210500

Glutamate Neurotransmitter Release Cycle

7 of 52

2.44

6.21

1.54e-13

MAP-112310

Neurotransmitter release cycle

7 of 110

2.12

4.8

1.11e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

8 of 188

1.94

4.51

2.46e-12

MAP-425407

SLC-mediated transmembrane transport

10 of 424

1.69

3.85

1.10e-13

MAP-112315

Transmission across Chemical Synapses

8 of 444

1.57

2.79

1.04e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11939

0.28

0.25

0.0081

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

5 of 403

1.41

1.19

0.0012

GOCC:0032809

Neuronal cell body membrane

2 of 17

2.38

1.15

0.0077

GOCC:0005886

Plasma membrane

8 of 2464

0.82

0.67

0.0012

GOCC:0016020

Membrane

10 of 4744

0.64

0.51

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

10 of 60

2.53

10.07

1.58e-22

KW-1133

Transmembrane helix

11 of 6003

0.58

0.5

5.45e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00375

Sodium:dicarboxylate symporter family

7 of 17

2.93

8.11

3.96e-16

PF00209

Sodium:neurotransmitter symporter family

3 of 44

2.15

1.49

0.0014

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