STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAX5B_007908Putative E3 ubiquitin-protein ligase HERC2-like. (4754 aa)    
Predicted Functional Partners:
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.782
SMAX5B_018361
Putative E3 SUMO-protein ligase RanBP2.
   
 0.729
UBE3A
Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
   
0.681
SMAX5B_022595
E3 SUMO-protein ligase PIAS4.
    
  0.677
ENSSMAP00000003962
Zinc finger, AN1-type domain 4.
    
 0.671
ENSSMAP00000008002
Ribosomal protein S27a.
    
 0.653
SMAX5B_003791
Putative suppressor of hairless protein-like.
   
 0.653
ENSSMAP00000015627
Recombination signal binding protein for immunoglobulin kappa J region-like.
   
 0.653
SMAX5B_007424
Putative recombining binding protein suppressor of hairless-like.
   
 0.653
SMAX5B_007890
Putative ubiquitin-protein ligase E3A-like.
   
0.649
Your Current Organism:
Scophthalmus maximus
NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot
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