SMAX5B_021191 protein (Scophthalmus maximus)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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SMAX5B_021191

Putative RNA-binding protein 34. (429 aa)

Predicted Functional Partners:

SMAX5B_013882

0.989

SMAX5B_001315

0.989

SMAX5B_000156

0.986

FTSJ3

0.981

SMAX5B_005573

0.979

SMAX5B_006998

0.979

SMAX5B_007805

0.975

SMAX5B_000267

0.975

SMAX5B_009855

0.974

ENSSMAP00000006348

0.974

Your Current Organism:

Scophthalmus maximus

NCBI taxonomy Id: 52904
Other names: Pleuronectes maximus, Psetta maxima, Rhombus maximus, S. maximus, turbot

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSMAP00000006348	FTSJ3	ENSSMAP00000006348	ENSSMAP00000004609	annotation not available	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.880
ENSSMAP00000006348	SMAX5B_000156	ENSSMAP00000006348	ENSSMAP00000012619	annotation not available	Putative CCAAT/enhancer-binding protein zeta-like.	0.975
ENSSMAP00000006348	SMAX5B_000267	ENSSMAP00000006348	ENSSMAP00000004474	annotation not available	Putative ATP-dependent RNA helicase DDX24 isoform 2.	0.979
ENSSMAP00000006348	SMAX5B_001315	ENSSMAP00000006348	ENSSMAP00000028618	annotation not available	Brix domain-containing protein 1 isoform 2.	0.956
ENSSMAP00000006348	SMAX5B_005573	ENSSMAP00000006348	ENSSMAP00000011298	annotation not available	Putative ATP-dependent RNA helicase DDX27; Belongs to the DEAD box helicase family.	0.976
ENSSMAP00000006348	SMAX5B_006998	ENSSMAP00000006348	ENSSMAP00000018566	annotation not available	Putative ATP-dependent RNA helicase DDX56 isoform 2.	0.955
ENSSMAP00000006348	SMAX5B_007805	ENSSMAP00000006348	ENSSMAP00000000392	annotation not available	Putative periodic tryptophan protein 1-like.	0.871
ENSSMAP00000006348	SMAX5B_009855	ENSSMAP00000006348	ENSSMAP00000006324	annotation not available	Putative RNA-binding protein 28.	0.747
ENSSMAP00000006348	SMAX5B_013882	ENSSMAP00000006348	ENSSMAP00000009625	annotation not available	Putative ribosome biogenesis protein BRX1-like.	0.957
ENSSMAP00000006348	SMAX5B_021191	ENSSMAP00000006348	ENSSMAP00000034253	annotation not available	Putative RNA-binding protein 34.	0.974
FTSJ3	ENSSMAP00000006348	ENSSMAP00000004609	ENSSMAP00000006348	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	annotation not available	0.880
FTSJ3	SMAX5B_000156	ENSSMAP00000004609	ENSSMAP00000012619	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative CCAAT/enhancer-binding protein zeta-like.	0.949
FTSJ3	SMAX5B_000267	ENSSMAP00000004609	ENSSMAP00000004474	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative ATP-dependent RNA helicase DDX24 isoform 2.	0.947
FTSJ3	SMAX5B_001315	ENSSMAP00000004609	ENSSMAP00000028618	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Brix domain-containing protein 1 isoform 2.	0.990
FTSJ3	SMAX5B_005573	ENSSMAP00000004609	ENSSMAP00000011298	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative ATP-dependent RNA helicase DDX27; Belongs to the DEAD box helicase family.	0.978
FTSJ3	SMAX5B_006998	ENSSMAP00000004609	ENSSMAP00000018566	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative ATP-dependent RNA helicase DDX56 isoform 2.	0.977
FTSJ3	SMAX5B_007805	ENSSMAP00000004609	ENSSMAP00000000392	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative periodic tryptophan protein 1-like.	0.876
FTSJ3	SMAX5B_009855	ENSSMAP00000004609	ENSSMAP00000006324	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative RNA-binding protein 28.	0.880
FTSJ3	SMAX5B_013882	ENSSMAP00000004609	ENSSMAP00000009625	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative ribosome biogenesis protein BRX1-like.	0.989
FTSJ3	SMAX5B_021191	ENSSMAP00000004609	ENSSMAP00000034253	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Putative RNA-binding protein 34.	0.981

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.64

expected number of edges:

10

PPI enrichment p-value:

0.00178

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002478

Antigen processing and presentation of exogenous peptide antigen

5 of 57

2.2

2.93

1.29e-06

GO:0002684

Positive regulation of immune system process

8 of 860

1.22

1.46

4.33e-06

GO:0019886

Antigen processing and presentation of exogenous peptide antigen via MHC class II

3 of 51

2.02

1.44

0.0016

GO:0002503

Peptide antigen assembly with MHC class II protein complex

3 of 47

2.06

1.44

0.0016

GO:0050863

Regulation of T cell activation

5 of 296

1.48

1.4

0.00037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0023026

MHC class II protein complex binding

4 of 50

2.16

2.19

4.88e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042611

MHC protein complex

5 of 51

2.25

3.44

1.06e-07

GO:0042612

MHC class I protein complex

2 of 3

3.08

1.5

0.0020

GO:0042613

MHC class II protein complex

3 of 48

2.05

1.4

0.0020

GO:0009897

External side of plasma membrane

4 of 476

1.18

0.68

0.0217

GO:0005886

Plasma membrane

10 of 4851

0.57

0.44

0.0021

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25783448

(2015) Evolutionary insights into host-pathogen interactions from mammalian sequence data.

4 of 31

2.36

2.95

1.91e-06

PMID:28515726

(2017) Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease.

2 of 25

2.16

0.79

0.0348

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28729

MHC class II, alpha chain, N-terminal, and MHC class II, beta chain, N-terminal

3 of 12

2.65

1.96

0.00025

CL:28691

Translocation of ZAP-70 to Immunological synapse, and MHC class II, alpha chain, N-terminal

4 of 96

1.87

1.7

0.00031

CL:32050

T cell costimulation, and Regulation of osteoclast development

2 of 5

2.86

1.54

0.0016

CL:28734

Regulation of macrophage migration inhibitory factor signaling pathway, and MHC class II, alpha chain, N-terminal

2 of 5

2.86

1.54

0.0016

CL:32019

Mixed, incl. TNFs bind their physiological receptors, and T cell receptor complex

3 of 53

2.01

1.51

0.0011

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04514

Cell adhesion molecules

7 of 300

1.62

2.67

2.24e-08

map04658

Th1 and Th2 cell differentiation

5 of 159

1.75

2.34

2.88e-06

map04659

Th17 cell differentiation

5 of 178

1.7

2.25

3.32e-06

map04612

Antigen processing and presentation

5 of 178

1.7

2.25

3.32e-06

map05321

Inflammatory bowel disease

4 of 131

1.74

1.92

4.63e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389948

PD-1 signaling

8 of 96

2.17

5.61

1.25e-13

MAP-388841

Costimulation by the CD28 family

8 of 157

1.96

4.56

2.75e-12

MAP-202430

Translocation of ZAP-70 to Immunological synapse

6 of 92

2.07

3.83

3.28e-09

MAP-202427

Phosphorylation of CD3 and TCR zeta chains

6 of 94

2.06

3.81

3.28e-09

MAP-202433

Generation of second messenger molecules

6 of 117

1.96

3.51

7.90e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001380

Mesentery

4 of 15

2.68

3.42

4.03e-07

BTO:0000784

Lymph node

4 of 98

1.86

1.88

0.00011

BTO:0000801

Macrophage

4 of 101

1.85

1.87

0.00011

BTO:0002273

Ileocecum

3 of 58

1.97

1.43

0.0015

BTO:0000289

Cytotoxic T-lymphocyte

2 of 9

2.6

1.32

0.0039

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042611

MHC protein complex

5 of 61

2.17

3.18

2.93e-07

GOCC:0098797

Plasma membrane protein complex

7 of 472

1.42

1.9

1.29e-06

GOCC:0042612

MHC class I protein complex

2 of 3

3.08

1.6

0.0013

GOCC:0042613

MHC class II protein complex

3 of 53

2.01

1.47

0.0013

GOCC:0042101

T cell receptor complex

2 of 20

2.25

1.02

0.0130

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0732

Signal

8 of 2545

0.75

0.57

0.0030

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001003

MHC class II, alpha chain, N-terminal

3 of 16

2.53

1.97

0.00022

IPR007110

Immunoglobulin-like domain

9 of 978

1.22

1.55

6.61e-07

IPR036179

Immunoglobulin-like domain superfamily

9 of 994

1.21

1.53

6.61e-07

IPR014745

MHC class II, alpha/beta chain, N-terminal

3 of 41

2.12

1.41

0.0020

IPR003597

Immunoglobulin C1-set

4 of 141

1.71

1.37

0.0012

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00920

Class II histocompatibility antigen, alpha domain

3 of 16

2.53

2.15

9.94e-05

SM00407

Immunoglobulin C-Type

4 of 139

1.71

1.59

0.00034

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