STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AIC47467.1Fructose-2,6-bisphosphatase. (385 aa)    
Predicted Functional Partners:
AIC47466.1
Zn-ribbon protein, possibly nucleic acid-binding.
 
  
 0.969
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.837
AIC47465.1
Dinuclear metal center protein, YbgI/SA1388 family.
  
  
 0.809
AIC47330.1
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
 
 0.796
AIC47378.1
Single-stranded DNA-binding protein.
   
 
 0.727
AIC48180.1
Single-stranded DNA-binding protein; Single-strand binding protein.
   
 
 0.727
topA
DNA topoisomerase I, bacterial; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removi [...]
   
 
 0.625
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.552
AIC47615.1
Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family.
 
    0.550
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
  
 0.547
Your Current Organism:
Rhodoluna lacicola
NCBI taxonomy Id: 529884
Other names: Candidatus Rhodoluna lacicola, DSM 23834, LMG 26932, LMG:26932, R. lacicola, Rhodoluna lacicola Hahn et al. 2014, actinobacterium MWH-Ta8, strain MWH-Ta8
Server load: low (16%) [HD]