node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIC47387.1 | glyA | Rhola_00005730 | Rhola_00011750 | Ribose 5-phosphate isomerase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.812 |
AIC47387.1 | upp | Rhola_00005730 | Rhola_00012570 | Ribose 5-phosphate isomerase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.789 |
AIC47547.1 | glyA | Rhola_00007430 | Rhola_00011750 | Orotidine 5'-phosphate decarboxylase, subfamily 2; Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.412 |
AIC47547.1 | guaA | Rhola_00007430 | Rhola_00011870 | Orotidine 5'-phosphate decarboxylase, subfamily 2; Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.666 |
AIC47547.1 | pyrH | Rhola_00007430 | Rhola_00005230 | Orotidine 5'-phosphate decarboxylase, subfamily 2; Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.934 |
AIC47547.1 | pyrR | Rhola_00007430 | Rhola_00007370 | Orotidine 5'-phosphate decarboxylase, subfamily 2; Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.996 |
AIC47547.1 | upp | Rhola_00007430 | Rhola_00012570 | Orotidine 5'-phosphate decarboxylase, subfamily 2; Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.972 |
AIC47887.1 | AIC47934.1 | Rhola_00010930 | Rhola_00011410 | Cytosine/adenosine deaminase. | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.904 |
AIC47887.1 | AIC47939.1 | Rhola_00010930 | Rhola_00011460 | Cytosine/adenosine deaminase. | Thymidine phosphorylase. | 0.900 |
AIC47887.1 | guaA | Rhola_00010930 | Rhola_00011870 | Cytosine/adenosine deaminase. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.449 |
AIC47887.1 | pyrR | Rhola_00010930 | Rhola_00007370 | Cytosine/adenosine deaminase. | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.900 |
AIC47887.1 | upp | Rhola_00010930 | Rhola_00012570 | Cytosine/adenosine deaminase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.924 |
AIC47934.1 | AIC47887.1 | Rhola_00011410 | Rhola_00010930 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Cytosine/adenosine deaminase. | 0.904 |
AIC47934.1 | AIC47939.1 | Rhola_00011410 | Rhola_00011460 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Thymidine phosphorylase. | 0.929 |
AIC47934.1 | guaA | Rhola_00011410 | Rhola_00011870 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.600 |
AIC47934.1 | pyrR | Rhola_00011410 | Rhola_00007370 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.900 |
AIC47934.1 | upp | Rhola_00011410 | Rhola_00012570 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.928 |
AIC47939.1 | AIC47887.1 | Rhola_00011460 | Rhola_00010930 | Thymidine phosphorylase. | Cytosine/adenosine deaminase. | 0.900 |
AIC47939.1 | AIC47934.1 | Rhola_00011460 | Rhola_00011410 | Thymidine phosphorylase. | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.929 |
AIC47939.1 | guaA | Rhola_00011460 | Rhola_00011870 | Thymidine phosphorylase. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.577 |