Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Psta_1672PFAM: histidine biosynthesis protein; KEGG: lch:Lcho_3137 histidine biosynthesis protein; Belongs to the HisA/HisF family. (251 aa)    
Predicted Functional Partners:
hisA
KEGG: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; K01814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein.
     
 0.916
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
     
 0.915
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
     
  0.900
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
     
  0.900
Psta_0060
KEGG: bph:Bphy_6507 formylmethanofuran dehydrogenase subunit C; TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: glutamate synthase alpha subunit domain protein.
 
   
 0.805
Psta_0063
TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; KEGG: noc:Noc_0024 DNA/RNA non-specific endonuclease.
 
   
 0.805
Psta_1617
Formylmethanofuran dehydrogenase subunit B-like protein; KEGG: noc:Noc_0025 formylmethanofuran dehydrogenase.
 
   
 0.805
Psta_3591
PFAM: protein of unknown function DUF201; KEGG: mca:MCA2868 hypothetical protein.
 
     0.801
Psta_3592
TIGRFAM: H4MPT-linked C1 transfer pathway protein; PFAM: Hydantoinase/oxoprolinase; KEGG: met:M446_5788 H4MPT-linked C1 transfer pathway protein.
 
     0.801
Psta_3593
PFAM: aspartate/glutamate/uridylate kinase; KEGG: mrd:Mrad2831_2724 aspartate/glutamate/uridylate kinase.
 
     0.801
Your Current Organism:
Pirellula staleyi
NCBI taxonomy Id: 530564
Other names: P. staleyi DSM 6068, Pirellula staleyi ATCC 27377, Pirellula staleyi DSM 6068, Pirellula staleyi str. DSM 6068, Pirellula staleyi strain DSM 6068
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